3-BROMO-5-FLUOROBENZALDEHYDE

3-BROMO-5-FLUOROBENZALDEHYDE Property

Melting point:

41-43℃

Boiling point:

231.0±20.0 °C(Predicted)

Density 

1.43

storage temp. 

Inert atmosphere,2-8°C

form 

Solid

Appearance

White to yellow <41°C Solid,>43°C Liquid

Water Solubility 

Slightly soluble in water.

Sensitive 

Light Sensitive

CAS DataBase Reference

188813-02-7(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2913000090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

3-BROMO-5-FLUOROBENZALDEHYDE Chemical Properties,Usage,Production

Uses

3-Bromo-5-fluorobenzaldehyde is an intermediate in organic syntheses. Reatant in the synthesis of 3,4-diamino-3-cyclobutene-1,2-diones, 9,10-Dihydro-9,10-diboraanthracenes.

Synthesis

A 2M isopropylmagnesium chloride solution (10 mL, 20 mmol) was dissolved in 5 mL of tetrahydrofuran under ice bath conditions. To this solution was added a tetrahydrofuran solution of 1,3-dibromo-5-fluorobenzene (4.0 g, 15.70 mmol) and the reaction mixture was stirred for 2 hours. The reaction system was then warmed to 20°C and the reaction was continued for 30 minutes. After completion of the reaction, the system was cooled to 0°C, N,N-dimethylformamide (2.5 mL, 31.50 mmol) was slowly added dropwise and the reaction was stirred at this temperature for 1.5 hours. After that, the reaction mixture was stirred at room temperature for 12 hours. At the end of the reaction, the reaction was quenched by adding saturated ammonium chloride solution (20 mL). The reaction mixture was extracted with ethyl acetate (50 mL x 3), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. Purification by silica gel column chromatography using eluent B afforded the target product 3-bromo-5-fluorobenzaldehyde (2.57 g, yellow liquid) in 81.0% yield.

References

[1] Patent: US6355648, 2002, B1. Location in patent: Page column 33-34
[2] Patent: CN103030646, 2016, B. Location in patent: Paragraph 0738; 0740-0743
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 4, p. 818 - 826
[4] Patent: US2007/88053, 2007, A1. Location in patent: Page/Page column 21
[5] Patent: CN105722823, 2016, A. Location in patent: Paragraph 0502; 0503