Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Product Name
- Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- CAS No.
- 231285-86-2
- Chemical Name
- Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Synonyms
- 1-methyl-5-trifluoromethyl-1H-pyrazole-4-ethyl carboxylate;4-(Ethoxycarbonyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole;Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;Ethyl 2-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate;Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 97%;1-Methyl-5-trifluoromethylpyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylicacid, 1-methyl-5-(trifluoromethyl)-, ethyl ester
- CBNumber
- CB02474515
- Molecular Formula
- C8H9F3N2O2
- Formula Weight
- 222.16
- MOL File
- 231285-86-2.mol
Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to off-white Solid
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- X6661
- Product name
- Ethyl1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Packaging
- 100mg
- Price
- $92
- Updated
- 2021/12/16
- Product number
- PC0541
- Product name
- Ethyl1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 4H23-3-10
- Product name
- Ethyl 2-methyl-3-(trifluoromethyl)pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $127
- Updated
- 2021/12/16
- Product number
- HCH0045536
- Product name
- ETHYL 2-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $870.87
- Updated
- 2021/12/16
- Product number
- A141814
- Product name
- Ethyl1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $368
- Updated
- 2021/12/16
Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
571-55-1
60-34-4
231285-86-2
General procedure: Intermediate 65a: Synthesis of ethyl 1-methyl-5-(trifluoromethyl)pyrazole-4-carboxylate 1. methylhydrazine (1.2 mL, 22.7 mmol) was slowly added to a mixture of concentrated hydrochloric acid. 2. HCl (1.95 mL, 23.7 mmol) and EtOH (1.9 mL) were added to the mixture at 0 °C and stirred at that temperature for 30 min. 3. the reaction mixture was diluted with EtOH (7.7 mL). 4. the resulting ethanol solution of methylhydrazine hydrochloride was slowly added to a solution of ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate (4.00 mL, 20.7 mmol) in EtOH (58 mL) at 0°C. 5. The reaction mixture was allowed to warm slowly to room temperature and stirred overnight. 6. The light yellow solution was concentrated in vacuum and the residue was suspended in water (20 mL). 7. Alkalize the aqueous phase with saturated aqueous NaHCO3, add Na2CO3 (20 mL) and extract with EtOAc (3 x 30 mL). 8. The organic layers were combined, washed with brine (30 mL), dried over Na2SO4, filtered and concentrated in vacuum. 9. The residue was purified by column chromatography (eluent: 0-50% EtOAc in heptane) to afford ethyl 1-methyl-5-(trifluoromethyl)pyrazole-4-carboxylate (2.91 g, 13.09 mmol, 64% yield) as a colorless oil. Characterization data: 1H NMR (CDCl3, 400 MHz) δ/ppm: 7.93 (1H, s), 4.34 (2H, q, J = 7.2 Hz), 4.09 (3H, s), 1.37 (3H, t, J = 7.2 Hz). 19F NMR (CDCl3, 400 MHz) δ/ppm: -57.1. MS (Method 2): RT: 1.62 min, m/z 223.0 [M + H]+.
References
[1] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00615; 00616; 00617
[2] Patent: CN104829605, 2018, B. Location in patent: Paragraph 0048-0051
Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate manufacturers
- Product
- Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 231285-86-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31