ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

Uses

Product Name: 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE
CAS No.: 944401-56-3
Chemical Name: 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE
Synonyms: 2-Amino-5-bromo-4-(trifL;5-Bromo-2-amino-4-trifluoromethylpyridine;2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE;5-bromo-4-(trifluoromethyl)-2-pyridylamine;5-Bromo-4-(trifluoromethyl)-2-pyridinamine;5-BroMo-4-trifluoroMethyl-pyridin-2-ylaMine;2-Pyridinamine, 5-bromo-4-(trifluoromethyl)-;2-Amino-5-bromo-4-(trifluoromethyl)pyridine,95%
CBNumber: CB02477309
Molecular Formula: C6H4BrF3N2
Formula Weight: 241.01
MOL File: 944401-56-3.mol

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2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE Property

Melting point:: 71-74℃
Boiling point:: 243.9±40.0 °C(Predicted)
Density: 1.790±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: soluble in Methanol
form: Solid
pka: 2.44±0.24(Predicted)
color: Pale yellow to orange
InChI: InChI=1S/C6H4BrF3N2/c7-4-2-12-5(11)1-3(4)6(8,9)10/h1-2H,(H2,11,12)
InChIKey: AEWYLVDLWQPJGW-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(Br)C(C(F)(F)F)=C1
CAS DataBase Reference: 944401-56-3

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-36-22
Safety Statements: 22-24/25-26-36/37/39
WGK Germany: 1
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 730483
Product name: 2-Amino-5-bromo-4-(trifluoromethyl)pyridine
Purity: 95%
Packaging: 500mg
Price: $52.7
Updated: 2023/06/20

TCI Chemical

Product number: A3256
Product name: 2-Amino-5-bromo-4-(trifluoromethyl)pyridine
Packaging: 1G
Price: $136
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FB105865
Product name: 5-bromo-4-(trifluoromethyl)pyridin-2-amine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 048313
Product name: 2-Amino-5-bromo-4-(trifluoromethyl)pyridine
Purity: 95%
Packaging: 500mg
Price: $62
Updated: 2021/12/16

Apolloscientific

Product number: PC48294
Product name: 2-Amino-5-bromo-4-(trifluoromethyl)pyridine
Packaging: 1g
Price: $67
Updated: 2021/12/16

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2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE Chemical Properties,Usage,Production

Uses

5-Bromo-4-(trifluoromethyl)pyridine-2-amine can be used as a pharmaceutical synthesis intermediate.

Synthesis

106447-97-6

944401-56-3

Step 1: Synthesis of 5-bromo-4-(trifluoromethyl)pyridin-2-amine To a stirred solution of 4-(trifluoromethyl)pyridin-2-amine (2.5 g, 15.42 mmol) in dichloromethane (250 mL) was added N-bromosuccinimide (2.74 g, 15.42 mmol) in batches. The reaction was carried out at room temperature and under light protection with continuous stirring for 6 hours. After completion of the reaction, the reaction mixture was diluted with 1N NaOH solution (20 mL) and extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the title compound (3.2 g, 86% yield). 1H NMR (400 MHz, CDCl3): δ 8.28 (s, 1H), 6.77 (s, 1H), 4.73 (brs, 2H). ESI-MS: Calculated: 239.95; Measured: 239.10 [M-H]?

References

[1] Patent: WO2017/219800, 2017, A1. Location in patent: Paragraph 00209; 00210
[2] Patent: CN105461714, 2016, A. Location in patent: Paragraph 0367; 0368; 0369
[3] Patent: CN103483345, 2016, B. Location in patent: Paragraph 0131-0134
[4] Patent: CN103694218, 2016, B. Location in patent: Paragraph 0093-0096
[5] Patent: WO2014/169167, 2014, A1. Location in patent: Page/Page column 56

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE Suppliers

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View Lastest Price from 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE manufacturers

Career Henan Chemical Co

Product: 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE 944401-56-3
Price: US $1.00/KG
Min. Order: 1IU
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-23

944401-56-3, 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINERelated Search:

5-broMo-6-Methoxy-1-indanone 5-Bromo-3-chloro-2-isobutoxy-pyridine 2-Chloro-4-(trifluoromethyl)pyridine 5-Chloro-4-(trifluoromethyl)pyridin-2-amine

2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

5-bromo-4-(trifluoromethyl)-2-pyridylamine

5-BroMo-4-trifluoroMethyl-pyridin-2-ylaMine

2-Pyridinamine, 5-bromo-4-(trifluoromethyl)-

5-Bromo-4-(trifluoromethyl)-2-pyridinamine

2-Amino-5-bromo-4-(trifL

2-Amino-5-bromo-4-(trifluoromethyl)pyridine,95%

5-Bromo-2-amino-4-trifluoromethylpyridine

944401-56-3