2-Fluoro-5-hydroxybenzenecarbonitrile

Product Name: 2-Fluoro-5-hydroxybenzenecarbonitrile
CAS No.: 104798-53-0
Chemical Name: 2-Fluoro-5-hydroxybenzenecarbonitrile
Synonyms: 2-Fluoro-5-hydroxybenzonitrile;3-Cyano-4-fluorophenol;2-Fluoro-5-hydroxybenzene;Fluoro-5-hydroxybenzonitrile;Benzonitrile, 2-fluoro-5-hydroxy-;2-Fluoro-5-hydroxybenzonitrile 98%;2-Fluoro-5-hydroxybenzenecarbonitrile
CBNumber: CB02480914
Molecular Formula: C7H4FNO
Formula Weight: 137.11
MOL File: 104798-53-0.mol

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2-Fluoro-5-hydroxybenzenecarbonitrile Property

Melting point:: 111-113°
Boiling point:: 268℃
Density: 1.34
Flash point:: 116℃
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 8.59±0.18(Predicted)
color: White to off-white
InChI: InChI=1S/C7H4FNO/c8-7-2-1-6(10)3-5(7)4-9/h1-3,10H
InChIKey: HFLYBTRQFOKYHC-UHFFFAOYSA-N
SMILES: C(#N)C1=CC(O)=CC=C1F

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Safety

HazardClass: IRRITANT
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F597993
Product name: 2-Fluoro-5-hydroxybenzenecarbonitrile
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-3-16
Product name: 2-Fluoro-5-hydroxybenzonitrile
Purity: 98%
Packaging: 5G
Price: $216
Updated: 2021/12/16

Matrix Scientific

Product number: 048695
Product name: 2-Fluoro-5-hydroxybenzenecarbonitrile
Purity: 95+%
Packaging: 25g
Price: $580
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0143612
Product name: 2-FLUORO-5-HYDROXYBENZONITRILE
Purity: 95.00%
Packaging: 1G
Price: $791.18
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0143612
Product name: 2-FLUORO-5-HYDROXYBENZONITRILE
Purity: 95.00%
Packaging: 5G
Price: $2813.58
Updated: 2021/12/16

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2-Fluoro-5-hydroxybenzenecarbonitrile Chemical Properties,Usage,Production

Chemical Properties

off-white crytalline

Synthesis

127667-01-0

104798-53-0

Example 2 Steps for the synthesis of 2,4-diaminoquinazolin-6-yl-2,5-dimethoxybenzoate (Compound 32): Step I: 2-fluoro-5-methoxybenzonitrile (10 g, 0.066 mol) was dissolved in dry dichloromethane (DCM, 200 ml) and cooled to 0 °C. Boron tribromide (BBr3, 16 ml, 0.0092 mol) was slowly added under stirring, followed by warming the reaction mixture to room temperature and continuous stirring for 2 days. After completion of the reaction, the reaction was quenched with 10% sodium bicarbonate solution (50 ml). The aqueous layer was separated and extracted with dichloromethane (2 x 200 ml). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the Step I product 2-fluoro-5-hydroxybenzonitrile (5.5 g, 61% yield). Thin layer chromatography (TLC) showed Rf = 0.4 (Expander: chloroform:methanol = 9:1).

References

[1] Patent: WO2008/152142, 2008, A1. Location in patent: Page/Page column 23

2-Fluoro-5-hydroxybenzenecarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-5-hydroxybenzenecarbonitrile Suppliers

China 106 India 1 United Kingdom 1 United States 8 Global 116

Shanghai AQBioPharma Co., Ltd.

Tel: 13661411401
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J & K SCIENTIFIC LTD.

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Beijing Eternalchem Co,. Ltd.

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Shanghai Sphchem Co., Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

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View Lastest Price from 2-Fluoro-5-hydroxybenzenecarbonitrile manufacturers

Changsha YuTeng New Materials Co., Ltd.

Product: 2-Fluoro-5-hydroxybenzenecarbonitrile 104798-53-0
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 97%
Supply Ability: 500kg/M
Release date: 2024-11-07

Honest Joy Holdings Limited

Product: 2-Fluoro-5-hydroxybenzenecarbonitrile 104798-53-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.2%
Supply Ability: 100 tons
Release date: 2022-01-17

Career Henan Chemical Co

Product: 2-Fluoro-5-hydroxybenzenecarbonitrile 104798-53-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2019-04-09

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