2-FLUORO-5-HYDROXYBENZOIC ACID
- Product Name
- 2-FLUORO-5-HYDROXYBENZOIC ACID
- CAS No.
- 51446-30-1
- Chemical Name
- 2-FLUORO-5-HYDROXYBENZOIC ACID
- Synonyms
- 3-Carboxy-4-fluorophenol;2-Fluoro-5-hydroxybenzoicaci;2-Fluro-5-Hydroxybenzoic Acid;2-fluoro-5-hydroxybenozicacid;2-FLUORO-5-HYDROXYBENZOIC ACID;Benzoic acid, 2-fluoro-5-hydroxy-
- CBNumber
- CB3151077
- Molecular Formula
- C7H5FO3
- Formula Weight
- 156.11
- MOL File
- 51446-30-1.mol
2-FLUORO-5-HYDROXYBENZOIC ACID Property
- Melting point:
- 201-203°C
- Boiling point:
- 354.8±27.0 °C(Predicted)
- Density
- 1.492±0.06 g/cm3(Predicted)
- storage temp.
- RT, stored under nitrogen
- pka
- 3.15±0.10(Predicted)
- form
- Powder
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 51446-30-1(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi,Xn
- Risk Statements
- 36/37/38-51-41-22
- Safety Statements
- 26-36-39
- Hazard Note
- Corrosive
- HazardClass
- IRRITANT
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F596048
- Product name
- 2-Fluoro-5-hydroxybenzoicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 009240
- Product name
- 2-Fluoro-5-hydroxybenzoic acid
- Packaging
- 5g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- X2155
- Product name
- 2-Fluoro-5-hydroxybenzoicacid
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- PC9534
- Product name
- 2-Fluoro-5-hydroxybenzoicacid
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 2629-3-10
- Product name
- 2-Fluoro-5-hydroxybenzoic acid
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
2-FLUORO-5-HYDROXYBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
off-white crytalline
Synthesis
1084801-91-1
51446-30-1
Step 1: Methyl 2-fluoro-5-hydroxybenzoate (30.0 g, 176.47 mmol, 1.0 eq.) was dissolved in a solvent mixture of THF and H2O (3:1 v/v, total 350 mL). To this solution was added LiOH-H2O (22.2 g, 529.41 mmol, 3.0 eq.) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, THF was removed by distillation under reduced pressure and the residue was diluted with cold water. The pH was adjusted to about 3 with 1.5 N HCl aqueous solution and the aqueous phase was extracted with EtOAc (3 x 250 mL). The organic phases were combined, washed with brine (150 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 2-fluoro-5-hydroxybenzoic acid as an off-white solid (25.1 g, 91% yield).MS m/z: [M-1]? = 155.4.
References
[1] Patent: WO2015/51043, 2015, A1. Location in patent: Paragraph 00248
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7818 - 7839
2-FLUORO-5-HYDROXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-5-HYDROXYBENZOIC ACID manufacturers
- Product
- 2-FLUORO-5-HYDROXYBENZOIC ACID 51446-30-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-19
- Product
- 2-FLUORO-5-HYDROXYBENZOIC ACID 51446-30-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-FLUORO-5-HYDROXYBENZOIC ACID 51446-30-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09