4-FLUORO-2-HYDROXYBENZOIC ACID
- Product Name
- 4-FLUORO-2-HYDROXYBENZOIC ACID
- CAS No.
- 345-29-9
- Chemical Name
- 4-FLUORO-2-HYDROXYBENZOIC ACID
- Synonyms
- 4-FLUOROSALICYCLIC ACID;uorosaL;RARECHEM AL BE 1428;Tavaborole Impurity 23;4-FLUOROSALICYLIC ACID;luorohydroxybenzoicacid;4-FluorosalicylicAcid>Azithromycin Impurity 51;4-Fluorosalicylicacid,98%;fluorohydroxybenzoicacid5
- CBNumber
- CB8663418
- Molecular Formula
- C7H5FO3
- Formula Weight
- 156.11
- MOL File
- 345-29-9.mol
4-FLUORO-2-HYDROXYBENZOIC ACID Property
- Melting point:
- 170 °C (dec.) (lit.)
- Boiling point:
- 300.5±27.0 °C(Predicted)
- Density
- 1.492±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in methanol.
- pka
- 2.85±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to orange
- BRN
- 2209124
- InChI
- InChI=1S/C7H5FO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
- InChIKey
- TTZOLDXHOCCNMF-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(F)C=C1O
- CAS DataBase Reference
- 345-29-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 554332
- Product name
- 4-Fluorosalicylic acid
- Purity
- 96%
- Packaging
- 1g
- Price
- $34.96
- Updated
- 2025/07/31
- Product number
- F0637
- Product name
- 4-Fluorosalicylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- F0637
- Product name
- 4-Fluorosalicylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $136
- Updated
- 2025/07/31
- Product number
- F0637
- Product name
- 4-Fluorosalicylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $405
- Updated
- 2025/07/31
- Product number
- F596145
- Product name
- 4-Fluoro-2-hydroxybenzoicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
4-FLUORO-2-HYDROXYBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
4-Fluorosalicylic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
General Description
4-Fluorosalicylic acid can be synthesized from the following compounds:
- 4-fluorotoluene
- m-fluorophenol
- 4-aminosalicylic acid
Synthesis
1583-58-0
345-29-9
General procedure for the synthesis of 4-fluorosalicylic acid from 2,4-difluorobenzoic acid: dimethylsulfoxide (DMSO, 4 L), 2,4-difluorobenzoic acid (500 g, 3.16 mol) and sodium hydroxide (NaOH, 253 g, 6.32 mol) were added to a dry 10 L four-neck flask. The mixture was heated to 130 °C and reacted for about 8 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction system was cooled to room temperature. Subsequently, the reaction solution was slowly poured into 40 L of ice water and the pH was adjusted to 2?3 with concentrated hydrochloric acid (care was taken that the temperature did not exceed 20 °C during the adjustment). At this time, a large amount of solid precipitated, continue to stir for 2 hours and then pump-filtered. The filter cake was washed with appropriate amount of water to obtain a white solid. The resulting solid was dried under reduced pressure at 60°C for 12 h. 450 g of 4-fluorosalicylic acid was finally obtained with a yield of 90% and a melting point of 184.9-185.2°C. The solid was dried at 60°C for 12 h under reduced pressure.
References
[1] Journal of Fluorine Chemistry, 2003, vol. 121, # 1, p. 97 - 99
[2] Patent: CN107501260, 2017, A. Location in patent: Paragraph 0030; 0031; 0033; 0034
[3] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 21, p. 5661 - 5675
[4] Patent: WO2013/148857, 2013, A1. Location in patent: Paragraph 00393; 00407; 00417
4-FLUORO-2-HYDROXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUORO-2-HYDROXYBENZOIC ACID manufacturers
- Product
- 4-FLUORO-2-HYDROXYBENZOIC ACID 345-29-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-06-04
- Product
- 4-FLUORO-2-HYDROXYBENZOIC ACID 345-29-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2023-03-27
- Product
- 4-FLUORO-2-HYDROXYBENZOIC ACID 345-29-9
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12