METHYL 4-FLUORO-2-HYDROXYBENZOATE

Product Name: METHYL 4-FLUORO-2-HYDROXYBENZOATE
CAS No.: 392-04-1
Chemical Name: METHYL 4-FLUORO-2-HYDROXYBENZOATE
Synonyms: Methyl 4-fl;RARECHEM AL BF 1428;METHYL 4-FLUOROSALICYLATE;Methyl 4-fluorosalicylate, 98+%;METHYL 4-FLUORO-2-HYDROXYBENZOATE;4-fluorosalicylic acid methyl ester;Methyl4-fluoro-2-hydroxybenzoate98%;Methyl 4-fluoro-2-hydroxybenzoate 98%;4-Fluoro-2-hydroxybenzoic acid methyl ester;4-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER
CBNumber: CB5727351
Molecular Formula: C8H7FO3
Formula Weight: 170.14
MOL File: 392-04-1.mol

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METHYL 4-FLUORO-2-HYDROXYBENZOATE Property

Melting point:: 38-40°C
Boiling point:: 225℃
Density: 1.309
Flash point:: 90℃
storage temp.: Sealed in dry,Room Temperature
form: crystalline solid
pka: 8.76±0.10(Predicted)
color: Off white to light yellow/brown
BRN: 2087920
CAS DataBase Reference: 392-04-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
Hazard Note: Irritant
HS Code: 2916310090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0834
Product name: Methyl 4-fluoro-2-hydroxybenzoate
Packaging: 1 g
Price: $73.1
Updated: 2025/07/31

TRC

Product number: M265025
Product name: Methyl4-Fluoro-2-hydroxybenzoate
Packaging: 1g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2629-3-08
Product name: Methyl 4-fluoro-2-hydroxybenzoate
Purity: 98%
Packaging: 1g
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: X3093
Product name: Methyl-4-fluoro-2-hydroxybenzoate
Packaging: 1g
Price: $83
Updated: 2021/12/16

Matrix Scientific

Product number: 075716
Product name: Methyl 4-fluoro-2-hydroxybenzoate
Purity: 95+%
Packaging: 5g
Price: $64
Updated: 2021/12/16

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METHYL 4-FLUORO-2-HYDROXYBENZOATE Chemical Properties,Usage,Production

Uses

Methyl 4-Fluoro-2-hydroxybenzoate is a useful synthetic intermediate. It was used to prepare benzo[d]isoxazol-3-ol as D-amino acid oxidase inhibitors. It is also used in the discovery of hydroxy-indazole-carboxamides as inhibitors of Hsp90.

Synthesis

67-56-1

345-29-9

392-04-1

To a solution of 100 g (0.64 mol, 1.0 eq.) of 4-fluoro-2-hydroxybenzoic acid (XLIa) dissolved in 1 L of methanol at 0 °C was slowly added 100 mL of concentrated sulfuric acid. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux at 70 °C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove most of the methanol. The concentrated residue was redissolved in 1 L of ethyl acetate and washed sequentially with 500 mL of saturated aqueous sodium bicarbonate and 500 mL of saturated saline. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford 95 g (0.56 mol, 87% yield) of methyl 4-fluoro-2-hydroxybenzoate (XLIIa).

References

[1] Chemical and Pharmaceutical Bulletin, 2012, vol. 60, # 2, p. 223 - 234
[2] Patent: WO2018/148204, 2018, A1. Location in patent: Page/Page column 176
[3] Patent: WO2018/172852, 2018, A1. Location in patent: Page/Page column 214; 222-223
[4] Patent: CN107501260, 2017, A. Location in patent: Paragraph 0030; 0031; 0032; 0035; 0036
[5] Acta Chemica Scandinavica, 1997, vol. 51, # 8, p. 881 - 888

METHYL 4-FLUORO-2-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-FLUORO-2-HYDROXYBENZOATE Suppliers

China 131 Germany 4 India 4 Italy 1 United Kingdom 3 United States 16 Global 159

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View Lastest Price from METHYL 4-FLUORO-2-HYDROXYBENZOATE manufacturers

Career Henan Chemical Co

Product: Methyl 4-fluoro-2-hydroxybenzoate 392-04-1
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-25

392-04-1, METHYL 4-FLUORO-2-HYDROXYBENZOATERelated Search:

METHYL 2,6-DIFLUORO-3-NITROBENZOATE METHYL 3-AMINO-2,6-DIFLUOROBENZOATE Methyl 3-formyl-2-nitrobenzoate Methyl 4-fluoro-5-Methoxy-2-nitrobenzoate METHYL 3-BROMO-2-OXO-2H-PYRAN-5-CARBOXYLATE Methyl 2-nitro-4-(trifluoromethyl)benzoate 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98% Benzoic acid, 4-fluoro-3-methoxy-5-nitro-, methyl ester Methyl 4-fluoro-3-nitrobenzoate Benzoic acid，4-fluoro-2,6-dimethyl-， methyl ester Methyl 4-fluoro-3-(trifluoroMethyl)benzoate Methyl 4-fluoro-3-methylbenzoate METHYL 4-FLUORO-3-HYDROXYBENZOATE methyl 4-fluoro-3-methoxyphenylacetate RARECHEM AL BF 0506 methyl 4-fluoro-2-methyl-3-nitrobenzoate 4-FLUORO-2-METHOXYBENZOIC ACID METHYL ESTER

Methyl 4-fl

4-Fluoro-2-hydroxybenzoic acid methyl ester

Methyl 4-fluorosalicylate, 5-Fluoro-2-(methoxycarbonyl)phenol

METHYL 4-FLUORO-2-HYDROXYBENZOATE

METHYL 4-FLUOROSALICYLATE

RARECHEM AL BF 1428

4-Fluorosalicylic acid methyl ester~Methyl 4-fluoro-2-hydroxybenzoate

Methyl4-fluorosalicylate~Methyl2-hydroxy-4-fluorobenzoate

4-fluorosalicylic acid methyl ester

Methyl 4-fluoro-2-hydroxybenzoate 98%

Methyl4-fluoro-2-hydroxybenzoate98%

4-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER

Methyl 4-fluorosalicylate, 98+%

Benzoic acid, 4-fluoro-2-hydroxy-, methyl ester

392-04-1

392-04-3

Benzoic acid

Acids & Esters

Fluorine Compounds

Phenols