Methyl 3-formyl-2-nitrobenzoate

Product Name: Methyl 3-formyl-2-nitrobenzoate
CAS No.: 138229-59-1
Chemical Name: Methyl 3-formyl-2-nitrobenzoate
Synonyms: Methyl 3-formyl-2-nitrobenzoate;Methyl 3-formyl-2-nitrobenzoate 99%;Benzoic acid, 3-forMyl-2-nitro-, Methyl ester;EOS-60871;RSYY(Roxadustat)-9;methyl 3-formyl-2-nitrobenzoa;methyl 2-nitro-3-aldehydebenzoate;Methyl ester 3-formyl-2-nitro-Benzoate;3-Formyl-2-nitrobenzoic acid methyl ester;Methyl 3-formyl-2-nitrobenzoate(For export only)
CBNumber: CB02534693
Molecular Formula: C9H7NO5
Formula Weight: 209.16
MOL File: 138229-59-1.mol

More

Less

Methyl 3-formyl-2-nitrobenzoate Property

Boiling point:: 354℃
Density: 1.386
Flash point:: 173℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: lumpy powder
color: White
InChI: InChI=1S/C9H7NO5/c1-15-9(12)7-4-2-3-6(5-11)8(7)10(13)14/h2-5H,1H3
InChIKey: NSLOBVGASZUPDO-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=CC(C=O)=C1[N+]([O-])=O
CAS DataBase Reference: 138229-59-1

More

Less

Safety

HS Code: 2918300090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More

Less

N-Bromosuccinimide Price

TRC

Product number: M305575
Product name: Methyl3-Formyl-2-nitrobenzoate
Packaging: 1g
Price: $405
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-1-2E
Product name: Methyl 3-formyl-2-nitrobenzoate
Purity: 99%
Packaging: 1g
Price: $432
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0393062
Product name: METHYL-3-FORMYL-2-NITROBENZOATE
Purity: 95.00%
Packaging: 5MG
Price: $502.56
Updated: 2021/12/16

AK Scientific

Product number: Y3235
Product name: Methyl3-formyl-2-nitrobenzoate
Packaging: 5g
Price: $54
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-1-2E
Product name: Methyl 3-formyl-2-nitrobenzoate
Purity: 99%
Packaging: 5G
Price: $1232
Updated: 2021/12/16

More

Less

Methyl 3-formyl-2-nitrobenzoate Chemical Properties,Usage,Production

Description

Methyl 3-formyl-2-nitrobenzoate is a phase transfer catalyst used to synthesize chlorinated hydrocarbons from inorganic chloride. It is soluble in organic solvents and can synthesize hydrochloric acid, sodium chloride, and zinc chloride. Methyl 3-formyl-2-nitrobenzoate is also used as a catalyst for producing polychlorinated biphenyls. It is hydrolyzed by water to release methyl 3-hydroxy-2-nitrobenzoate.

Uses

Methyl 3-?Formyl-?2-?nitrobenzoate is a reagent used in the synthesis of PARP inhibitors. Intermediate of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Synthesis

132874-06-7

138229-59-1

Step C: Synthesis of methyl 3-formyl-2-nitrobenzoate; N-methylmorpholine oxide (NMO, 6.10 g, 52.07 mmol) was added to a solution of acetonitrile (150 mL) containing methyl 3-(bromomethyl)-2-nitrobenzoate (7.13 g, 26.023 mmol) and 4A molecular sieves (35.32 g) under nitrogen protection. The reaction mixture was stirred at room temperature for 1.5 hours. Subsequently, the reaction mixture was diluted with ethyl acetate (600 mL) and the insoluble material was removed by vacuum filtration. The filtrate was washed sequentially with water (100 mL), 1N HCl (100 mL) and brine (150 mL) and then dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by fast column chromatography on silica gel, using ethyl acetate/hexane (1:3) as eluent to afford methyl 3-formyl-2-nitrobenzoate as an off-white solid (4.04 g, 74% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 3.95 (s, 3H), 7.77 (t, 1H), 8.18 (dd, 1H), 8.28 (dd, 1H), 9.98 (s, 1H).

References

[1] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 88-89
[2] Patent: WO2009/87381, 2009, A1. Location in patent: Page/Page column 35-36
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 22, p. 7170 - 7185
[4] Organic Process Research and Development, 2011, vol. 15, # 4, p. 831 - 840
[5] Patent: WO2007/113596, 2007, A1. Location in patent: Page/Page column 77

Methyl 3-formyl-2-nitrobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl 3-formyl-2-nitrobenzoate Suppliers

China 212 India 7 United Kingdom 2 United States 11 Global 232

Anhui nuoquan pharmaceutical co. LTD

Tel: 15705561919
Fax: 0556-5032869
Email: chunli.yi@nuozhanchem.com
Country: China
ProdList: 101
Advantage: 55

Nanjing Lebang Pharmaceutical Technology Co., Ltd

Tel: 18860950986
Email: tangmanman@lebangpharma.com
Country: China
ProdList: 650
Advantage: 58

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 28-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 510
Advantage: 57

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Synches Co., Ltd.

Tel: 021-53292253
Fax: 021-53292253
Email: biz@synches.com
Country: China
ProdList: 199
Advantage: 64

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Wuhan ariel chemical Co., LTD.

Tel: 18986259541
Fax: 027-87840182
Email: sales@3stc.com
Country: China
ProdList: 3763
Advantage: 58

More

Less

View Lastest Price from Methyl 3-formyl-2-nitrobenzoate manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: methyl 3-formyl-2-nitrobenzoate 138229-59-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Formyl-2-nitrobenzoic acid methyl ester 138229-59-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl 3-formyl-2-nitrobenzoate 138229-59-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-13

138229-59-1, Methyl 3-formyl-2-nitrobenzoateRelated Search:

4-(3-Piperidyl)aniline Dihydrochloride 1H-indazole-7-carboxylic acid tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate Niraparib (S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Piperidine, 3-(4-bromophenyl)- (aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate 4-piperidin-3-ylaniline CHEMBRDG-BB 7959525 4,6-Dibromo-3-hydroxypyridine-2-carboxylic acid methyl ester METHYL 3-BROMO-2-OXO-2H-PYRAN-5-CARBOXYLATE Methyl 2-nitro-4-(trifluoromethyl)benzoate METHYL 4-FLUORO-2-HYDROXYBENZOATE 3-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER Methyl 4-(4,4,4-trifluorobutanoyl)benzoate METHYL 2,6-DIFLUORO-3-NITROBENZOATE METHYL 3-AMINO-2,6-DIFLUOROBENZOATE

Methyl 3-formyl-2-nitrobenzoate 99%

EOS-60871

Methyl 3-formyl-2-nitrobenzoate

Benzoic acid, 3-forMyl-2-nitro-, Methyl ester

methyl 3-formyl-2-nitrobenzoa

3-Formyl-2-nitrobenzoic acid methyl ester

methyl 2-nitro-3-aldehydebenzoate

Methyl ester 3-formyl-2-nitro-Benzoate

Methyl 3-formyl-2-nitrobenzoate(For export only)

RSYY(Roxadustat)-9

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((2-(4-((S)-piperidin-3-yl)phenyl)-2H-indazole-7-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

138229-59-1