Methyl 4-fluoro-2-methylbenzoate

Product Name: Methyl 4-fluoro-2-methylbenzoate
CAS No.: 174403-69-1
Chemical Name: Methyl 4-fluoro-2-methylbenzoate
Synonyms: RARECHEM AL BF 0506;Baloxavir Impurity 58;Baloxavir Marboxil Impurity 58;methyl 2-methyl-4-fluorobenzoate;methyl 4-fluoro-2-methylbenzoate;Propiconazole Impurity 10 (Bromuconazole);4-Floro-2-methylbenzoic acid methyl ester;2-Methyl-4-fluorobenzoic acid methyl ester;4-Fluoro-2-methylbenzoic acid methyl ester;BENZOIC ACID,4-FLUORO-2-METHYL-,METHYL ESTER
CBNumber: CB8343435
Molecular Formula: C9H9FO2
Formula Weight: 168.16
MOL File: 174403-69-1.mol

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Methyl 4-fluoro-2-methylbenzoate Property

Boiling point:: 206℃
Density: 1.137
Flash point:: 77℃
storage temp.: Sealed in dry,Room Temperature
form: Liquid
color: Colorless

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M321520
Product name: Methyl4-Fluoro-2-methylbenzoate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: X2849
Product name: Methyl4-fluoro-2-methylbenzoate
Packaging: 5g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC901494
Product name: Methyl4-fluoro-2-methylbenzoate
Purity: 98%
Packaging: 25g
Price: $115
Updated: 2021/12/16

Apolloscientific

Product number: PC901494
Product name: Methyl4-fluoro-2-methylbenzoate
Purity: 98%
Packaging: 100g
Price: $300
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044008
Product name: METHYL 4-FLUORO-2-METHYLBENZOATE
Purity: 95.00%
Packaging: 2G
Price: $409.2
Updated: 2021/12/16

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Methyl 4-fluoro-2-methylbenzoate Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

Methyl 4-fluoro-2-methylbenzoate is an impurity of baloxavir and can be used for new drug application and research.

Synthesis

67-56-1

321-21-1

174403-69-1

Step 1. Synthesis of methyl 4-fluoro-2-methylbenzoate: 4-fluoro-2-methylbenzoic acid (50 g, 324.38 mmol) was mixed with thionyl chloride (SOCl2, 77 g, 648.76 mmol) in methanol (200 mL), and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to afford methyl 4-fluoro-2-methylbenzoate as a brown oil (52 g, 95% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 7.92-7.98 (m, 1H), 6.88-6.95 (m, 2H), 3.90 (s, 3H), 2.61 (s, 3H).

References

[1] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 60
[2] Patent: WO2010/69966, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: US6342504, 2002, B1. Location in patent: Page column 119
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 24, p. 6707 - 6713
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1628 - 1631

Methyl 4-fluoro-2-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-fluoro-2-methylbenzoate Suppliers

China 102 Germany 1 India 2 Switzerland 1 United Kingdom 1 United States 10 Global 117

Alfa Aesar

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Energy Chemical

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Tianjin Jinyuda Chemical Co., Ltd.

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Shanghai Topbiochem Technology Co., Ltd

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View Lastest Price from Methyl 4-fluoro-2-methylbenzoate manufacturers

Career Henan Chemical Co

Product: RARECHEM AL BF 0506 174403-69-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 500kg/month
Release date: 2019-08-01

174403-69-1, Methyl 4-fluoro-2-methylbenzoateRelated Search:

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RARECHEM AL BF 0506

BENZOIC ACID,4-FLUORO-2-METHYL-,METHYL ESTER

4-Fluoro-2-methylbenzoic acid methyl ester

4-Floro-2-methylbenzoic acid methyl ester

2-Methyl-4-fluorobenzoic acid methyl ester

methyl 2-methyl-4-fluorobenzoate

Baloxavir Marboxil Impurity 58

methyl 4-fluoro-2-methylbenzoate

Baloxavir Impurity 58

Propiconazole Impurity 10 (Bromuconazole)

4-Fluoro-2-methylbenzoic acid methyl ester 98%

174403-69-1