ChemicalBook > CAS DataBase List > Methyl 4-fluoro-2-methylbenzoate

Methyl 4-fluoro-2-methylbenzoate

Product Name
Methyl 4-fluoro-2-methylbenzoate
CAS No.
174403-69-1
Chemical Name
Methyl 4-fluoro-2-methylbenzoate
Synonyms
RARECHEM AL BF 0506;Baloxavir Impurity 58;Baloxavir Marboxil Impurity 58;methyl 2-methyl-4-fluorobenzoate;methyl 4-fluoro-2-methylbenzoate;Propiconazole Impurity 10 (Bromuconazole);4-Floro-2-methylbenzoic acid methyl ester;2-Methyl-4-fluorobenzoic acid methyl ester;4-Fluoro-2-methylbenzoic acid methyl ester;BENZOIC ACID,4-FLUORO-2-METHYL-,METHYL ESTER
CBNumber
CB8343435
Molecular Formula
C9H9FO2
Formula Weight
168.16
MOL File
174403-69-1.mol
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Methyl 4-fluoro-2-methylbenzoate Property

Boiling point:
206℃
Density 
1.137
Flash point:
77℃
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
color 
Colorless
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Safety

HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M321520
Product name
Methyl4-Fluoro-2-methylbenzoate
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
X2849
Product name
Methyl4-fluoro-2-methylbenzoate
Packaging
5g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC901494
Product name
Methyl4-fluoro-2-methylbenzoate
Purity
98%
Packaging
25g
Price
$115
Updated
2021/12/16
Apolloscientific
Product number
PC901494
Product name
Methyl4-fluoro-2-methylbenzoate
Purity
98%
Packaging
100g
Price
$300
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0044008
Product name
METHYL 4-FLUORO-2-METHYLBENZOATE
Purity
95.00%
Packaging
2G
Price
$409.2
Updated
2021/12/16
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Methyl 4-fluoro-2-methylbenzoate Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

Methyl 4-fluoro-2-methylbenzoate is an impurity of baloxavir and can be used for new drug application and research.

Synthesis

67-56-1

321-21-1

174403-69-1

Step 1. Synthesis of methyl 4-fluoro-2-methylbenzoate: 4-fluoro-2-methylbenzoic acid (50 g, 324.38 mmol) was mixed with thionyl chloride (SOCl2, 77 g, 648.76 mmol) in methanol (200 mL), and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to afford methyl 4-fluoro-2-methylbenzoate as a brown oil (52 g, 95% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 7.92-7.98 (m, 1H), 6.88-6.95 (m, 2H), 3.90 (s, 3H), 2.61 (s, 3H).

References

[1] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 60
[2] Patent: WO2010/69966, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: US6342504, 2002, B1. Location in patent: Page column 119
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 24, p. 6707 - 6713
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1628 - 1631

Methyl 4-fluoro-2-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-fluoro-2-methylbenzoate Suppliers

China 102 Germany 1 India 2 Switzerland 1 United Kingdom 1 United States 10 Global 117
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View Lastest Price from Methyl 4-fluoro-2-methylbenzoate manufacturers

Career Henan Chemical Co
Product
RARECHEM AL BF 0506 174403-69-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

174403-69-1, Methyl 4-fluoro-2-methylbenzoateRelated Search:

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  • RARECHEM AL BF 0506
  • BENZOIC ACID,4-FLUORO-2-METHYL-,METHYL ESTER
  • 4-Fluoro-2-methylbenzoic acid methyl ester
  • 4-Floro-2-methylbenzoic acid methyl ester
  • 2-Methyl-4-fluorobenzoic acid methyl ester
  • methyl 2-methyl-4-fluorobenzoate
  • Baloxavir Marboxil Impurity 58
  • methyl 4-fluoro-2-methylbenzoate
  • Baloxavir Impurity 58
  • Propiconazole Impurity 10 (Bromuconazole)
  • 4-Fluoro-2-methylbenzoic acid methyl ester 98%
  • 174403-69-1