METHYL 4-FORMYL-3-HYDROXYBENZOATE

Product Name: METHYL 4-FORMYL-3-HYDROXYBENZOATE
CAS No.: 24589-98-8
Chemical Name: METHYL 4-FORMYL-3-HYDROXYBENZOATE
Synonyms: ethyl 4-forMyl-3-hydroxybenzoate;4-CarboMethoxysalicylaldehyde;methyl 4-formyl-3-hydoxybenzoate;METHYL 4-FORMYL-3-HYDROXYBENZOATE;Benzoic acid, 4-formyl-3-hydroxy-, methyl ester
CBNumber: CB02615936
Molecular Formula: C9H8O4
Formula Weight: 180.16
MOL File: 24589-98-8.mol

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METHYL 4-FORMYL-3-HYDROXYBENZOATE Property

Melting point:: 135-135.5 °C(Solv: ethyl acetate (141-78-6))
Boiling point:: 324.1±27.0 °C(Predicted)
Density: 1.310±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.36±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C9H8O4/c1-13-9(12)6-2-3-7(5-10)8(11)4-6/h2-5,11H,1H3
InChIKey: OMCTZIDLDSYPOA-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(C=O)C(O)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C177725
Product name: 4-Carbomethoxysalicylaldehyde
Packaging: 1g
Price: $1320
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 55403
Product name: 4-Carbomethoxysalicylaldehyde
Packaging: 250mg
Price: $290
Updated: 2021/12/16

AK Scientific

Product number: 6190BB
Product name: Methyl4-formyl-3-hydroxybenzoate
Packaging: 5g
Price: $860
Updated: 2021/12/16

Ambeed

Product number: A116776
Product name: Methyl4-formyl-3-hydroxybenzoate
Purity: 95%
Packaging: 100mg
Price: $47
Updated: 2021/12/16

Ambeed

Product number: A116776
Product name: Methyl4-formyl-3-hydroxybenzoate
Purity: 95%
Packaging: 250mg
Price: $74
Updated: 2021/12/16

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METHYL 4-FORMYL-3-HYDROXYBENZOATE Chemical Properties,Usage,Production

Uses

4-Carbomethoxysalicylaldehyde is used in the preparation of α-glucosidase inhibitors. Also used in the preparation of β-lactamase substrates.

Synthesis

67-56-1

619-12-5

24589-98-8

Step 1: Synthesis of methyl 4-formyl-3-hydroxybenzoate (239) 4-Formyl-3-hydroxybenzoic acid (1.2 g, 7.22 mmol) was dissolved in methanol (10 ml). Sulfoxide chloride (1.054 ml, 14.45 mmol) was added slowly and the reaction mixture was stirred at 60 °C for 3 h to ensure complete reaction. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was ground with hexane and subsequently filtered to afford methyl 4-formyl-3-hydroxybenzoate (1.3 g, 7.22 mmol, 100% yield) as a white solid. Mass spectrometric analysis (MS/ESI+) showed the molecular ion peak m/z 181.04 [MH]+.

References

[1] Patent: US2014/155391, 2014, A1. Location in patent: Paragraph 0617; 0618
[2] Patent: US2012/245144, 2012, A1. Location in patent: Page/Page column 105
[3] Journal of the American Chemical Society, 1955, vol. 77, p. 973,979
[4] Journal of Medicinal Chemistry, 1969, vol. 12, # 3, p. 420 - 424
[5] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 5, p. 1175 - 1183

METHYL 4-FORMYL-3-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-FORMYL-3-HYDROXYBENZOATE Suppliers

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24589-98-8, METHYL 4-FORMYL-3-HYDROXYBENZOATERelated Search:

METHYL 5-CYANO-2-METHOXYBENZOATE Methyl 4-broMo-2-chloro-5-fluorobenzoate Methyl 5-bromomethyl-2-nitro-benzoate Methyl 4-(bromomethyl)-2,5-dichlorobenzoate methyl 5-bromo-2-methoxybenzoate methyl 5-chloro-2-formylbenzoate methyl 5-formyl-2-nitrobenzoate Methyl 5-broMo-2-fluoro-3-nitrobenzoate 5-BroMo-2,4-difluoro-benzoic acid Methyl ester Methyl 4-hydroxy-2-methylbenzoate METHYL 5-BROMO-2-IODOBENZOATE Methyl 5-nitro-2-(trifluoromethyl)benzoate Methyl 5-aMino-2-iodobenzoate methyl 5-amino-2-(trifluoromethyl)benzoate methyl 4-bromo-2-formylbenzoate Methyl 4-bromo-2,6-dichlorobenzoate Methyl 4-formyl-3-methylbenzoate RARECHEM AL BF 0506

METHYL 4-FORMYL-3-HYDROXYBENZOATE

ethyl 4-forMyl-3-hydroxybenzoate

4-CarboMethoxysalicylaldehyde

methyl 4-formyl-3-hydoxybenzoate

Benzoic acid, 4-formyl-3-hydroxy-, methyl ester

24589-98-8

Aromatics, Miscellaneous Reagents