METHYL 4-FORMYL-3-HYDROXYBENZOATE
- Product Name
- METHYL 4-FORMYL-3-HYDROXYBENZOATE
- CAS No.
- 24589-98-8
- Chemical Name
- METHYL 4-FORMYL-3-HYDROXYBENZOATE
- Synonyms
- ethyl 4-forMyl-3-hydroxybenzoate;4-CarboMethoxysalicylaldehyde;methyl 4-formyl-3-hydoxybenzoate;METHYL 4-FORMYL-3-HYDROXYBENZOATE;Benzoic acid, 4-formyl-3-hydroxy-, methyl ester
- CBNumber
- CB02615936
- Molecular Formula
- C9H8O4
- Formula Weight
- 180.16
- MOL File
- 24589-98-8.mol
METHYL 4-FORMYL-3-HYDROXYBENZOATE Property
- Melting point:
- 135-135.5 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 324.1±27.0 °C(Predicted)
- Density
- 1.310±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.36±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C9H8O4/c1-13-9(12)6-2-3-7(5-10)8(11)4-6/h2-5,11H,1H3
- InChIKey
- OMCTZIDLDSYPOA-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(C=O)C(O)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C177725
- Product name
- 4-Carbomethoxysalicylaldehyde
- Packaging
- 1g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 55403
- Product name
- 4-Carbomethoxysalicylaldehyde
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 6190BB
- Product name
- Methyl4-formyl-3-hydroxybenzoate
- Packaging
- 5g
- Price
- $860
- Updated
- 2021/12/16
- Product number
- 24589988
- Product name
- Methyl3-hydroxy-4-formylbenzoate
- Packaging
- 500mg
- Price
- $863.9
- Updated
- 2021/12/16
- Product number
- A116776
- Product name
- Methyl4-formyl-3-hydroxybenzoate
- Purity
- 95%
- Packaging
- 10g
- Price
- $965
- Updated
- 2021/12/16
METHYL 4-FORMYL-3-HYDROXYBENZOATE Chemical Properties,Usage,Production
Uses
4-Carbomethoxysalicylaldehyde is used in the preparation of α-glucosidase inhibitors. Also used in the preparation of β-lactamase substrates.
Synthesis
67-56-1
619-12-5
24589-98-8
Step 1: Synthesis of methyl 4-formyl-3-hydroxybenzoate (239) 4-Formyl-3-hydroxybenzoic acid (1.2 g, 7.22 mmol) was dissolved in methanol (10 ml). Sulfoxide chloride (1.054 ml, 14.45 mmol) was added slowly and the reaction mixture was stirred at 60 °C for 3 h to ensure complete reaction. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was ground with hexane and subsequently filtered to afford methyl 4-formyl-3-hydroxybenzoate (1.3 g, 7.22 mmol, 100% yield) as a white solid. Mass spectrometric analysis (MS/ESI+) showed the molecular ion peak m/z 181.04 [MH]+.
References
[1] Patent: US2014/155391, 2014, A1. Location in patent: Paragraph 0617; 0618
[2] Patent: US2012/245144, 2012, A1. Location in patent: Page/Page column 105
[3] Journal of the American Chemical Society, 1955, vol. 77, p. 973,979
[4] Journal of Medicinal Chemistry, 1969, vol. 12, # 3, p. 420 - 424
[5] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 5, p. 1175 - 1183