ChemicalBook > CAS DataBase List > METHYL 4-FLUORO-2-HYDROXYBENZOATE
METHYL 4-FLUORO-2-HYDROXYBENZOATE
- Product Name
- METHYL 4-FLUORO-2-HYDROXYBENZOATE
- CAS No.
- 392-04-1
- Chemical Name
- METHYL 4-FLUORO-2-HYDROXYBENZOATE
- Synonyms
- Methyl 4-fl;RARECHEM AL BF 1428;METHYL 4-FLUOROSALICYLATE;Methyl 4-fluorosalicylate, 98+%;METHYL 4-FLUORO-2-HYDROXYBENZOATE;4-fluorosalicylic acid methyl ester;Methyl4-fluoro-2-hydroxybenzoate98%;Methyl 4-fluoro-2-hydroxybenzoate 98%;4-Fluoro-2-hydroxybenzoic acid methyl ester;4-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER
- CBNumber
- CB5727351
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 392-04-1.mol
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METHYL 4-FLUORO-2-HYDROXYBENZOATE Property
- Melting point:
- 38-40°C
- Boiling point:
- 225℃
- Density
- 1.309
- Flash point:
- 90℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline solid
- pka
- 8.76±0.10(Predicted)
- color
- Off white to light yellow/brown
- BRN
- 2087920
- CAS DataBase Reference
- 392-04-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- JRD0834
- Product name
- Methyl 4-fluoro-2-hydroxybenzoate
- Packaging
- 1 g
- Price
- $73.1
- Updated
- 2025/07/31
TRC
- Product number
- M265025
- Product name
- Methyl4-Fluoro-2-hydroxybenzoate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 075716
- Product name
- Methyl 4-fluoro-2-hydroxybenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 075716
- Product name
- Methyl 4-fluoro-2-hydroxybenzoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $64
- Updated
- 2021/12/16
AK Scientific
- Product number
- X3093
- Product name
- Methyl-4-fluoro-2-hydroxybenzoate
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
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METHYL 4-FLUORO-2-HYDROXYBENZOATE Chemical Properties,Usage,Production
Uses
Methyl 4-Fluoro-2-hydroxybenzoate is a useful synthetic intermediate. It was used to prepare benzo[d]isoxazol-3-ol as D-amino acid oxidase inhibitors. It is also used in the discovery of hydroxy-indazole-carboxamides as inhibitors of Hsp90.
Synthesis
67-56-1
345-29-9
392-04-1
To a solution of 100 g (0.64 mol, 1.0 eq.) of 4-fluoro-2-hydroxybenzoic acid (XLIa) dissolved in 1 L of methanol at 0 °C was slowly added 100 mL of concentrated sulfuric acid. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux at 70 °C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove most of the methanol. The concentrated residue was redissolved in 1 L of ethyl acetate and washed sequentially with 500 mL of saturated aqueous sodium bicarbonate and 500 mL of saturated saline. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford 95 g (0.56 mol, 87% yield) of methyl 4-fluoro-2-hydroxybenzoate (XLIIa).
References
[1] Chemical and Pharmaceutical Bulletin, 2012, vol. 60, # 2, p. 223 - 234
[2] Patent: WO2018/148204, 2018, A1. Location in patent: Page/Page column 176
[3] Patent: WO2018/172852, 2018, A1. Location in patent: Page/Page column 214; 222-223
[4] Patent: CN107501260, 2017, A. Location in patent: Paragraph 0030; 0031; 0032; 0035; 0036
[5] Acta Chemica Scandinavica, 1997, vol. 51, # 8, p. 881 - 888
METHYL 4-FLUORO-2-HYDROXYBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 4-FLUORO-2-HYDROXYBENZOATE manufacturers
Career Henan Chemical Co
- Product
- Methyl 4-fluoro-2-hydroxybenzoate 392-04-1
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-25
392-04-1, METHYL 4-FLUORO-2-HYDROXYBENZOATERelated Search:
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