3-Methyl-4-(4-morpholinyl)aniline
- Product Name
- 3-Methyl-4-(4-morpholinyl)aniline
- CAS No.
- 112900-82-0
- Chemical Name
- 3-Methyl-4-(4-morpholinyl)aniline
- Synonyms
- 3-Methyl-4-morpholinoaniline;3-methyl-4-morpholin-4-ylaniline;3-Methyl-4-(4-morpholinyl)aniline;3-methyl-4-(4-morpholinyl)Benzenamine;Benzenamine, 3-methyl-4-(4-morpholinyl)-
- CBNumber
- CB02481744
- Molecular Formula
- C11H16N2O
- Formula Weight
- 192.26
- MOL File
- 112900-82-0.mol
3-Methyl-4-(4-morpholinyl)aniline Property
- Boiling point:
- 373.8±42.0 °C(Predicted)
- Density
- 1.122±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 7.25±0.40(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- M725413
- Product name
- 3-Methyl-4-morpholinoaniline
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- OR910928
- Product name
- 3-Methyl-4-morpholinoaniline
- Purity
- 96%
- Packaging
- 1g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 051300
- Product name
- 3-Methyl-4-(4-morpholinyl)aniline
- Packaging
- 2.500g
- Price
- $377
- Updated
- 2021/12/16
- Product number
- 051300
- Product name
- 3-Methyl-4-(4-morpholinyl)aniline
- Packaging
- 500mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- OR910928
- Product name
- 3-Methyl-4-morpholinoaniline
- Purity
- 96%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
3-Methyl-4-(4-morpholinyl)aniline Chemical Properties,Usage,Production
Synthesis
223404-63-5
112900-82-0
General procedure for the synthesis of 3-methyl-4-morpholinoaniline from 4-(2-methyl-4-nitrophenyl)morpholine: a mixture of 4-(2-methyl-4-nitrophenyl)morpholine (6 g, 0.0645 mol, 1.0 eq.) and zinc powder (8.64 g, 0.135 mol, 5 eq.) in methanol (50 mL) in a round-bottomed flask was placed under stirring conditions . Ammonium chloride (7.29 g, 0.135 mol, 5 eq.) was slowly added at 0 °C, followed by stirring the reaction mixture at room temperature for 1 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated under reduced pressure to obtain the residue. The residue was diluted with dichloromethane (DCM, 150 mL) and washed with water. The organic layer was separated, washed with brine solution, dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to give 3-methyl-4-morpholinoaniline as a brown solid (5 g, 96.35% yield).1H NMR (400 MHz, CDCl3) data: δ 6.768 (d, 1H), 6.39 (s, 1H), 6.36 (d, 1H), 4.66 ( brs, 2H), 3.681 (t, 4H), 2.683 (t, 4H), 2.124 (s, 3H).
References
[1] Patent: WO2005/105761, 2005, A1. Location in patent: Page/Page column 36
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119
[3] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 94; 95
[4] Patent: CN108690043, 2018, A. Location in patent: Paragraph 0262; 0266-0267
[5] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 4, p. 353 - 360
3-Methyl-4-(4-morpholinyl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methyl-4-(4-morpholinyl)aniline Suppliers
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- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
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View Lastest Price from 3-Methyl-4-(4-morpholinyl)aniline manufacturers
- Product
- 3-Methyl-4-(4-morpholinyl)aniline 112900-82-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11