7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
- Product Name
- 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
- CAS No.
- 600734-06-3
- Chemical Name
- 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
- Synonyms
- Bay 65-1942 HCl;KINK-1 hydrochloride;Bay 65-1942 (HCl salt);Bay 65-1942 (hydrochloride);KINK-1 hydrochloride >=98% (HPLC);Bay 651942 hydrochloride,Bay 65 1942 hydrochloride;(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride;7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride;2H-Pyrido[2,3-d][1,3]oxazin-2-one,7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-,Hydrochloride(1:1)
- CBNumber
- CB02484912
- Molecular Formula
- C22H25N3O4.ClH
- Formula Weight
- 431.917
- MOL File
- 600734-06-3.mol
7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Property
- storage temp.
- -20°C
- solubility
- DMSO : 50 mg/mL (115.76 mM; Need ultrasonic)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -19 to -24°, c = 0.2 in DMF
N-Bromosuccinimide Price
- Product number
- SML2098
- Product name
- KINK-1 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $82.4
- Updated
- 2024/03/01
- Product number
- SML2098
- Product name
- KINK-1 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $658
- Updated
- 2024/03/01
- Product number
- CS-0623
- Product name
- Bay65-1942hydrochloride
- Purity
- 99.22%
- Packaging
- 10mg
- Price
- $840
- Updated
- 2021/12/16
- Product number
- orb611402
- Product name
- Bay 65-1942 hydrochloride
- Packaging
- 10mg
- Price
- $853.4
- Updated
- 2021/12/16
- Product number
- A3230
- Product name
- Bay65-1942HClsalt
- Packaging
- 10mg
- Price
- $1084
- Updated
- 2021/12/16
7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Chemical Properties,Usage,Production
Biochem/physiol Actions
KINK-1 (Kinase Inhibitor of NF-ΚB-1; Bay 65-1942; CmpdA; Compound A) is an ATP-competitive, IKKβ-selective IΚB kinase (IKK) inhibitor (Ki against ATP = 2 nM/IKKβ and 135 nM/IKKα) that potently inhibits IKKβ-catalyzed GST-IΚBα(1–54) phosphorylation (IC50 = 4 nM, 200 nM ATP) without affecting (IC50 >10μM) IKK3 or 27 other kinases, lipases, phosphatases, caspases, and MMPs. KINK-1 effectively inhibits NF-ΚB activation and cytokines production in various human and murine cultures (IC50 from 18 to 502 nM) and is efficacious against LPS-induced plasma TNF-α production in mice and rats in vivo (EC50 = 9.1 and 6.6 mg/kg p.o., repectively) with good pharmacokinetic profile and oral availability. KINK-1 is also shown to effectively inhibit OVA-induced lung inflammation in a rat model of asthma (ED50 <0.3 mg/kg p.o.) without adverse effects to the animals.
7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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