Amuvatinib

ChemicalBook > CAS DataBase List > Amuvatinib

Product Name: Amuvatinib
CAS No.: 850879-09-3
Chemical Name: Amuvatinib
Synonyms: AMuvatinib;Mp470;HPK 56;CS-460;MP470;HPK 56;MP-470(MP 470);AMuvatinib (MP-470);MP-470 (Amuvatinib);MP470 AMUVATINIB (MP-470);Amuvatinib, 10 mM in DMSO
CBNumber: CB02484967
Molecular Formula: C23H21N5O3S
Formula Weight: 447.51
MOL File: 850879-09-3.mol

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Amuvatinib Property

Density: 1.443
storage temp.: Store at -20°C
solubility: ≥22.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
color: White to off-white
CAS DataBase Reference: 850879-09-3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21461
Product name: Amuvatinib
Purity: ≥98%
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 21461
Product name: Amuvatinib
Purity: ≥98%
Packaging: 5mg
Price: $218
Updated: 2024/03/01

Cayman Chemical

Product number: 21461
Product name: Amuvatinib
Purity: ≥98%
Packaging: 10mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 21461
Product name: Amuvatinib
Purity: ≥98%
Packaging: 25mg
Price: $812
Updated: 2024/03/01

TRC

Product number: A822578
Product name: Amuvatinib
Packaging: 5mg
Price: $335
Updated: 2021/12/16

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Amuvatinib Chemical Properties,Usage,Production

Description

Amuvatinib (also known as MP-470 or 850879-09-3), is a multi-targeted inhibitor of receptor tyrosine kinases that inhibits c-Kit, platelet-derived growth factor receptor α (PDGFRα), and c-Met (IC50s = 10, 40, and 81 nM, respectively). It inhibits growth and induces apoptosis in prostate cancer cell lines, with additive effects achieved when combined with erlotinib . Amuvatinib sensitizes cancer cells to radiation and chemotherapeutic compounds, in part by inhibiting homologous recombination.

Uses

MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

Definition

ChEBI: N-(1,3-benzodioxol-5-ylmethyl)-4-(4-benzofuro[3,2-d]pyrimidinyl)-1-piperazinecarbothioamide is a N-arylpiperazine.

Clinical Use

Amivantamab is the first drug approved by the FDA for the treatment of patients with NSCLC and EGFR exon 20 insertion mutations.

target

c-KitD816H

Mode of action

Μechanisticly, amuvatinib inhibits tyrosine kinase receptor KIT through occupying its ATP binding domain (IC50 < 0.1 μM) and disrupts DNA repair through suppression of homologous recombination protein Rad51 as well as synergistic effects in combination with double stranded DNA damaging agents.

References

1. Effects of combining amuvatinib (MP-470) with DNA-damaging agents in osteosarcoma cell lines
2. Janssen submits supplemental biologics license application to the U.S. Food and Drug Administration seeking approval of RYBREVANT? (amivantamab-vmjw) in combination with chemotherapy for the first-line treatment of patients with locally advanced or metastatic EGFR exon 20 insertion mutation-positive non-small cell lung cancer. News release.
3. Raoul Tibes, Gil Fine, Gavin Choy, Sanjeev Redkar, Pietro Taverna, Aram Oganesian, Amarpao Sahai, Mohammad Azab and Anthony W. Tolcher. A phase I, first-in-human dose-escalation study of amuvatinib, a multi-targeted tyrosine kinase inhibitor, in patients with advanced solid tumors. Cancer Chemother Pharmacol (2013) 71: 463-471
4. Gavin Choy, Rajashree Joshi-Hangal, Aram Oganesian, Gil Fine, Scott Rasmussen, Joanne Collier, James Kissling, Amarpal Sahai, Mohammad Azab and Sanjeev Redkar. Saftety, tolerability, and pharmacokinetics of amuvatinib from three phase 1 clinical studies in healthy volunteers. Cancer Chemother Pharmacol (2012) 70: 183-190

Amuvatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Amuvatinib manufacturers

Career Henan Chemical Co

Product: N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide 850879-09-3
Price: US $500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100kg
Release date: 2018-08-04

850879-09-3, AmuvatinibRelated Search:

Everolimus Axitinib SNS-032 Dasatinib Mocetinostat (MGCD0103) Foretinib (GSK1363089)

N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide

1-Piperazinecarbothioamide, N-(1,3-benzodioxol-5-ylmethyl)-4-benzofuro(3,2-D)pyrimidin-4-yl-

Mp470

AMuvatinib

HPK 56

MP-470(MP 470)

AMuvatinib (MP-470)

AMuvatinib (MP-470, HPK 56)

MP470 AMUVATINIB (MP-470)

MP 470 N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide

N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide Amuvatinib(MP470 )

MP470 (MP-470, Amuvatinib)

CS-460

MP-470 (Amuvatinib)

MP-470; MP 470; MP470; HPK 56

N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro-[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioam

N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide

AMUVATINIB (MP-470);MP-470; MP 470; MP470; HPK 56

MP470;HPK 56

N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide USP/EP/BP

Amuvatinib, 10 mM in DMSO

850879-09-3

Inhibitors

Inhibitor