AT9283
- Product Name
- AT9283
- CAS No.
- 896466-04-9
- Chemical Name
- AT9283
- Synonyms
- CS-48;J-504568;AT9283, >=98%;AT-9283; AT 9283;AT9283 AKSci SYN1011 AT-9283;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283
- CBNumber
- CB02484987
- Molecular Formula
- C19H23N7O2
- Formula Weight
- 381.43
- MOL File
- 896466-04-9.mol
AT9283 Property
- Density
- 1.45
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 10.58±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 11496
- Product name
- AT-9283
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 11496
- Product name
- AT-9283
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- 11496
- Product name
- AT-9283
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- 11496
- Product name
- AT-9283
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $445
- Updated
- 2024/03/01
- Product number
- A790300
- Product name
- AT-9283
- Packaging
- 25mg
- Price
- $445
- Updated
- 2021/12/16
AT9283 Chemical Properties,Usage,Production
Uses
AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.[Cayman Chemical]
Definition
ChEBI: 1-cyclopropyl-3-[3-[5-(4-morpholinylmethyl)-2-benzimidazolylidene]-1,2-dihydropyrazol-4-yl]urea is a member of benzimidazoles.
Biological Activity
at9283, a synthetic small heterocyclic molecule discovered using a fragment-based approach, is a novel inhibitor of aurora kinase, a family of serine/threonine kinases regulating both mitosis and meiosis, that potently inhibits aurora kinases a and b, with 50% inhibition concentration ic50 value of 3 nm, as well as janus kinases (jaks), abelson kinase (bcrabl t315i) and flt-3. at9283 has been found to be therapeutic in leukemic cells, myeloproliferative disorders and multiple solid tumor cell lines. study results have shown that at9283 exhibits anti-proliferative activity and induces polyploidy and apoptosis in aggressive b-cell nhl cell lines associated with inhibition of aurora kinase b.qi w, liu x, cooke ls, persky do, miller tp, squires m, mahadevan d. at9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive b-cell lymphomas. int j cancer. 2012 jun 15;130(12):2997-3005. doi: 10.1002/ijc.26324. epub 2011 nov 19.arkenau ht, plummer r, molife lr, olmos d, yap ta, squires m, lewis s, lock v, yule m, lyons j, calvert h, judson i. a phase i dose escalation study of at9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies. ann oncol. 2012 may;23(5):1307-13. doi: 10.1093/annonc/mdr451. epub 2011 oct 19.
target
Aurora A
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View Lastest Price from AT9283 manufacturers
- Product
- AT9283 896466-04-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24