JNJ-7706621

Product Name: JNJ-7706621
CAS No.: 443797-96-4
Chemical Name: JNJ-7706621
Synonyms: CS-409;JNJ-7706621 USP/EP/BP;JNJ7706621; JNJ 7706621;Aurora Kinase/Cdk Inhibitor;JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor;Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide;Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-;Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase
CBNumber: CB62484646
Molecular Formula: C15H12F2N6O3S
Formula Weight: 394.36
MOL File: 443797-96-4.mol

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JNJ-7706621 Property

Melting point:: 149-155℃
Boiling point:: 676.6±65.0 °C(Predicted)
Density: 1.71
storage temp.: +2C to +8C
solubility: Soluble in DMSO at 15mg/ml
form: White solid
pka: 9.80±0.12(Predicted)
color: White to off-white
Sensitive: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 189406
Product name: Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
Packaging: 5mg
Price: $403
Updated: 2024/03/01

Alfa Aesar

Product number: J65997
Product name: Aurora Kinase/Cdk Inhibitor
Packaging: 5mg
Price: $379
Updated: 2023/06/20

Cayman Chemical

Product number: 18494
Product name: JNJ-7706621
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18494
Product name: JNJ-7706621
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18494
Product name: JNJ-7706621
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

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JNJ-7706621 Chemical Properties,Usage,Production

Description

JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC₅₀s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity for these enzymes over a panel of other receptors and kinases, although it exhibits submicromolar inhibition of VEGF and FGF receptors, as well as GSK3β. JNJ-7706621 blocks the growth of a large variety of cancer cell lines (IC₅₀ values range from 112 to 514 nM), with lower potency against normal cells (IC₅₀ values between 3.67 and 5.42 μM). It induces the regression of A375 melanoma human tumor xenografts in mice. JNJ-7706621 is a substrate for the ATP-binding cassette transporter G2, also known as breast cancer resistance protein.

Uses

JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing''s sarcoma.

Definition

ChEBI: 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide is a sulfonamide.

target

CDK1

JNJ-7706621 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ-7706621 Suppliers

China 97 Germany 1 India 2 United Kingdom 1 United States 20 Global 121

CAREBIO PHARMA

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Shanghai Boyle Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Jinan Trio PharmaTech Co., Ltd.

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Xi’an chemsoar Medical Technology Co., ltd

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Dalian Meilun Biotech Co., Ltd.

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Shanghai civi chemical technology co.,Ltd

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NCE Biomedical Co.,Ltd.

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443797-96-4, JNJ-7706621Related Search:

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4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide JNJ7706621

4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide

Aurora Kinase/Cdk Inhibitor

Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

CS-409

JNJ7706621; JNJ 7706621

Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-

4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide

JNJ-7706621 USP/EP/BP

JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor

Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase

443797-96-4

C15H12F2N6O3S

Inhibitor

Inhibitors