ChemicalBook > CAS DataBase List > JNJ-7706621

JNJ-7706621

Product Name
JNJ-7706621
CAS No.
443797-96-4
Chemical Name
JNJ-7706621
Synonyms
CS-409;JNJ-7706621 USP/EP/BP;JNJ7706621; JNJ 7706621;Aurora Kinase/Cdk Inhibitor;JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor;Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide;Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-;Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase
CBNumber
CB62484646
Molecular Formula
C15H12F2N6O3S
Formula Weight
394.36
MOL File
443797-96-4.mol
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JNJ-7706621 Property

Melting point:
149-155℃
Boiling point:
676.6±65.0 °C(Predicted)
Density 
1.71
storage temp. 
+2C to +8C
solubility 
Soluble in DMSO at 15mg/ml
form 
White solid
pka
9.80±0.12(Predicted)
color 
White to off-white
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
189406
Product name
Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
Packaging
5mg
Price
$403
Updated
2024/03/01
Alfa Aesar
Product number
J65997
Product name
Aurora Kinase/Cdk Inhibitor
Packaging
5mg
Price
$379
Updated
2023/06/20
Cayman Chemical
Product number
18494
Product name
JNJ-7706621
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18494
Product name
JNJ-7706621
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
18494
Product name
JNJ-7706621
Purity
≥98%
Packaging
10mg
Price
$341
Updated
2024/03/01
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JNJ-7706621 Chemical Properties,Usage,Production

Description

JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC50s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity for these enzymes over a panel of other receptors and kinases, although it exhibits submicromolar inhibition of VEGF and FGF receptors, as well as GSK3β. JNJ-7706621 blocks the growth of a large variety of cancer cell lines (IC50 values range from 112 to 514 nM), with lower potency against normal cells (IC50 values between 3.67 and 5.42 μM). It induces the regression of A375 melanoma human tumor xenografts in mice. JNJ-7706621 is a substrate for the ATP-binding cassette transporter G2, also known as breast cancer resistance protein.

Uses

JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing''s sarcoma.

Definition

ChEBI: 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide is a sulfonamide.

target

CDK1

JNJ-7706621 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ-7706621 Suppliers

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443797-96-4, JNJ-7706621Related Search:

JNJ0966 JNJ-38158471 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine TRC253 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine JNJ 63533054 JNJ-26481585 N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide JNJ 31020028 JNJ-10229570 JNJ-632 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide ZM 447439 Ribociclib Orantinib (SU6668) BI-D1870 CCT129202 AT9283

  • 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide JNJ7706621
  • 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide
  • Aurora Kinase/Cdk Inhibitor
  • Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
  • CS-409
  • JNJ7706621; JNJ 7706621
  • Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-
  • 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
  • JNJ-7706621 USP/EP/BP
  • JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor
  • Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase
  • 443797-96-4
  • C15H12F2N6O3S
  • Inhibitor
  • Inhibitors