ChemicalBook > CAS DataBase List > JNJ-38158471

JNJ-38158471

Product Name
JNJ-38158471
CAS No.
951151-97-6
Chemical Name
JNJ-38158471
Synonyms
CS-2660;JNJ-38158471;CS-2660 (JNJ-38158471);JNJ-38158471, 10 mM in DMSO;CS-2660 (JNJ-38158471) ，S0377;1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea;1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea;(E)-1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea;Urea, N-[4-[[6-amino-5-[(methoxyimino)methyl]-4-pyrimidinyl]oxy]-2-chlorophenyl]-N'-ethyl-;VEGFR-2,JNJ 38158471,VEGFR,cancer,SCFR,malignancies,JNJ38158471,Kit,c-Kit,CD117,RET,Vascular endothelial growth factor receptor,JNJ-38158471,inhibit,Inhibitor
CBNumber
CB92621141
Molecular Formula
C15H17ClN6O3
Formula Weight
364.79
MOL File
951151-97-6.mol
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JNJ-38158471 Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 30 mg/mL (82.24 mM);Ethanol: Insoluble
pka
13.06±0.70(Predicted)
form 
Solid
color 
Gray to brown
Water Solubility 
Water: Insoluble
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
SYN1133
Product name
JNJ-38158471
Packaging
1mg
Price
$210
Updated
2021/12/16
Adipogen Life Sciences
Product number
SYN-1133-M100
Product name
JNJ-38158471
Purity
≥95%
Packaging
100mg
Price
$2317
Updated
2021/12/16
Ambeed
Product number
A1324667
Product name
1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea
Purity
98+%
Packaging
5mg
Price
$80
Updated
2021/12/16
Ambeed
Product number
A1324667
Product name
1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea
Purity
98+%
Packaging
10mg
Price
$135
Updated
2021/12/16
Ambeed
Product number
A1324667
Product name
1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea
Purity
98+%
Packaging
25mg
Price
$175
Updated
2021/12/16
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JNJ-38158471 Chemical Properties,Usage,Production

Uses

JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively[1].

in vivo

JNJ-38158471 (10 or 100 mg/kg; p.o.; once-daily) inhibits VEGF-induced corneal neovascularization[1].
JNJ-38158471 (10-200 mg/kg; p.o.) inhibits the growth of human tumor xenografts in a dose-dependent manner in both A431 and HCT116 models. JNJ-38158471 treatment is well tolerated, following continuous administration for 24 days, body weights were comparable with control animals[1].
JNJ-38158471 (100 mg/kg; p.o.; once-daily) treatment shows statistically signi?cant activity compare with vehicle treat animals. The body weights of both JNJ-38158471-treated and vehicle-treated groups were comparable at study end[1].

Animal Model:Female C57BL/6J mice are implanted with rhVEGF165[1]
Dosage:10 or 100 mg/kg
Administration:Daily oral administration for 6 days
Result:Caused a marked and apparently dose-dependent inhibition of VEGF-dependent blood vessel formation (100 mg/kg, resulted in 83% inhibition; 10 mg/kg, resulted in 15% inhibition).
Animal Model:Female athymic nude mice; 5-6 weeks; implanted subcutaneously human colorectal carcinoma cells (HCT116) or human epidermoid carcinoma cells (A431)[1]
Dosage:10, 50, 100, 200 mg/kg
Administration:Oral administration for 35 days
Result:Achieved optimum ef?cacy with the dose from 100 to 200 mg/kg daily.
Animal Model:Female athymic nude mice; 5-6 weeks; implanted subcutaneously human skin melanoma cells (A375)[1]
Dosage:100 mg/kg
Administration:Once-daily oral administration for 28 days
Result:Inhibited 90% growth of tumor with daily doses of 100 mg/kg.
Animal Model:Female C57BL/6J-Apc Min mice; 5 weeks of age[1]
Dosage:100 mg/kg
Administration:Once-daily oral administration for two weeks
Result:Inhibited polyp formation in the transgenic APC min-mouse model.

IC 50

VEGFR-2: 40 nM (IC50); RET: 180 nM (IC50); c-Kit: 500 nM (IC50)

References

[1] Kenneth RL, et, al. A Highly Selective, Orally Bioavailable, Vascular Endothelial Growth Factor receptor-2 Tyrosine Kinase Inhibitor Has Potent Activity in Vitro and in Vivo. Angiogenesis. 2009; 12(3): 287-96. DOI:10.1007/s10456-009-9151-7

JNJ-38158471 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ-38158471 Suppliers

China 43 United Kingdom 1 United States 5 Global 49
SYN|thesis med chem P/L
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+86-021-50720296
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+86-021-50720297
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service@synkinase.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Pharmacodia (Beijing) Co.,Ltd
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+86-400-851-9921
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+86-10-82826195
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sales@pharmacodia.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
Email
info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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China
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8011
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Lynnchem
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86-(0)29-85992781 17792393971
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Novachemistry
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United Kingdom
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951151-97-6, JNJ-38158471Related Search:

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  • JNJ-38158471
  • (E)-1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea
  • CS-2660
  • 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea
  • 1-(4-((6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yl)oxy)-2-chlorophenyl)-3-ethylurea
  • CS-2660 (JNJ-38158471)
  • VEGFR-2,JNJ 38158471,VEGFR,cancer,SCFR,malignancies,JNJ38158471,Kit,c-Kit,CD117,RET,Vascular endothelial growth factor receptor,JNJ-38158471,inhibit,Inhibitor
  • Urea, N-[4-[[6-amino-5-[(methoxyimino)methyl]-4-pyrimidinyl]oxy]-2-chlorophenyl]-N'-ethyl-
  • JNJ-38158471, 10 mM in DMSO
  • CS-2660 (JNJ-38158471) ，S0377
  • 951151-97-6
  • C15H17ClN6O3