JNJ0966

Product Name: JNJ0966
CAS No.: 315705-75-0
Chemical Name: JNJ0966
Synonyms: JNJ0966;JNJ0966, 10 mM in DMSO;JNJ0966;JNJ 0966;JNJ-0966;315705-75-0;N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide;N-(2-((2-Methoxyphenyl)amino)-4'-methyl-[4,5'-bithiazol]-2'-yl)acetamide;Inhibitor,Matrix metalloproteinases,JNJ0966,JNJ 0966,MMP,JNJ-0966,inhibit;Acetamide, N-[2-[(2-methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-
CBNumber: CB93386490
Molecular Formula: C16H16N4O2S2
Formula Weight: 360.45
MOL File: 315705-75-0.mol

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JNJ0966 Property

storage temp.: Store at -20°C
solubility: DMSO:63.34(Max Conc. mg/mL);175.72(Max Conc. mM)
form: A crystalline solid
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2588
Product name: JNJ0966
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $91.86
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2588
Product name: JNJ0966
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $270.9
Updated: 2025/07/31

Tocris

Product number: 6439
Product name: JNJ0966
Purity: ≥98%(HPLC)
Packaging: 10
Price: $179
Updated: 2021/12/16

Tocris

Product number: 6439
Product name: JNJ0966
Purity: ≥98%(HPLC)
Packaging: 50
Price: $752
Updated: 2021/12/16

TRC

Product number: J211590
Product name: JNJ0966
Packaging: 5mg
Price: $580
Updated: 2021/12/16

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JNJ0966 Chemical Properties,Usage,Production

Uses

JNJ0966, is a highly selective MMP-9 zymogen inhibitor.

Biological Activity

JNJ0966 is a potent and highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation. It appears th at JNJ0966 binds to a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106. JNJ0966 reduces disease severity in in a mouse experimental autoimmune encephalomyelitis (EAE) model. JNJ0966 does not inhibit activation of MMP-2 zymogen, and has no effect on MMP-1, MMP-2, MMP-3, MMP-9 or MMP-14 catalytic activity.

in vivo

The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose^[1].

storage

Store at -20°C

JNJ0966 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ0966 Suppliers

China 65 United Kingdom 1 United States 7 Global 73

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315705-75-0, JNJ0966Related Search:

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JNJ0966

N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide

JNJ0966;JNJ 0966;JNJ-0966;315705-75-0

Acetamide, N-[2-[(2-methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-

Inhibitor,Matrix metalloproteinases,JNJ0966,JNJ 0966,MMP,JNJ-0966,inhibit

N-(2-((2-Methoxyphenyl)amino)-4'-methyl-[4,5'-bithiazol]-2'-yl)acetamide

JNJ0966, 10 mM in DMSO

315705-75-0

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