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JNJ 31020028

Product Name
JNJ 31020028
CAS No.
1094873-14-9
Chemical Name
JNJ 31020028
Synonyms
CS-1745;JNJ 31020028;JNJ31020028, >98%;JNJ 31020028 ，S6416;JNJ-31020028?, >98%;JNJ-31020028;JNJ 31020028;1-Piperazineacetamide, N,N-diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-α-phenyl-;N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide;N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide;4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE
CBNumber
CB32627994
Molecular Formula
C34H36FN5O2
Formula Weight
565.68
MOL File
1094873-14-9.mol
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JNJ 31020028 Property

Boiling point:
677.5±55.0 °C(Predicted)
Density 
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
form 
Powder
pka
12.14±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
5mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
10mg
Price
$268
Updated
2024/03/01
Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
25mg
Price
$586
Updated
2024/03/01
Usbiological
Product number
474118
Product name
JNJ-31020028
Packaging
100mg
Price
$1507
Updated
2021/12/16
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JNJ 31020028 Chemical Properties,Usage,Production

Description

JNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y2 over Y1, Y4, and Y5 receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pKB = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC50 = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y2 receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.

Uses

JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease[1].

in vivo

JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals[1].

Animal Model:Stressed and nonstressed male Sprague-Dawley rats[1]
Dosage:0, 3, 10 and 20 mg/kg
Administration:Subcutaneous injection; 0-20 mg/kg once
Result:Significantly decreased plasma corticosterone levels in stressed animals, but not significantly affected plasma corticosterone levels in nonstressed animals. Attenuated effects of stress on refeeding.

References

[1] Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y DOI:10.1007/s00213-009-1726-x

JNJ 31020028 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ 31020028 Suppliers

China 78 India 1 United States 14 Global 93
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
Country
China
ProdList
472
Advantage
55
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
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View Lastest Price from JNJ 31020028 manufacturers

Career Henan Chemical Co
Product
JNJ 31020028 1094873-14-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

1094873-14-9, JNJ 31020028Related Search:

JNJ-10229570 JNJ0966 JNJ-38158471 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine TRC253 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine JNJ-7706621 JNJ 63533054 JNJ-26481585 N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide JNJ-632 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide

  • JNJ 31020028
  • N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide
  • N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide
  • 4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE
  • JNJ31020028, >98%
  • JNJ-31020028?, >98%
  • CS-1745
  • JNJ-31020028;JNJ 31020028
  • 1-Piperazineacetamide, N,N-diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-α-phenyl-
  • hypothalamus,JNJ-31020028,anxiety,microdialysis,depression,JNJ31020028,norepinephrine,NPY receptor,Neuropeptide Y Receptor,Inhibitor,stress-induced anorexia,inhibit
  • JNJ 31020028 ，S6416
  • 1094873-14-9
  • C34H36FN5O2
  • Inhibitors