JNJ 31020028
- Product Name
- JNJ 31020028
- CAS No.
- 1094873-14-9
- Chemical Name
- JNJ 31020028
- Synonyms
- CS-1745;JNJ 31020028;JNJ31020028, >98%;JNJ-31020028?, >98%;JNJ-31020028;JNJ 31020028;1-Piperazineacetamide, N,N-diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-α-phenyl-;N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide;N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide;4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE;hypothalamus,JNJ-31020028,anxiety,microdialysis,depression,JNJ31020028,norepinephrine,NPY receptor,Neuropeptide Y Receptor,Inhibitor,stress-induced anorexia,inhibit
- CBNumber
- CB32627994
- Molecular Formula
- C34H36FN5O2
- Formula Weight
- 565.68
- MOL File
- 1094873-14-9.mol
JNJ 31020028 Property
- Boiling point:
- 677.5±55.0 °C(Predicted)
- Density
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
- form
- Powder
- pka
- 12.14±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- 18407
- Product name
- JNJ-31020028
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 18407
- Product name
- JNJ-31020028
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 18407
- Product name
- JNJ-31020028
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $268
- Updated
- 2024/03/01
- Product number
- 18407
- Product name
- JNJ-31020028
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $586
- Updated
- 2024/03/01
- Product number
- 474118
- Product name
- JNJ-31020028
- Packaging
- 100mg
- Price
- $1507
- Updated
- 2021/12/16
JNJ 31020028 Chemical Properties,Usage,Production
Description
JNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y2 over Y1, Y4, and Y5 receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pKB = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC50 = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y2 receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.
JNJ 31020028 Preparation Products And Raw materials
Raw materials
Preparation Products
JNJ 31020028 Suppliers
View Lastest Price from JNJ 31020028 manufacturers
- Product
- JNJ 31020028 1094873-14-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05