ChemicalBook > CAS DataBase List > JNJ 31020028

JNJ 31020028

Product Name
JNJ 31020028
CAS No.
1094873-14-9
Chemical Name
JNJ 31020028
Synonyms
CS-1745;JNJ 31020028;JNJ31020028, >98%;JNJ-31020028?, >98%;JNJ-31020028;JNJ 31020028;1-Piperazineacetamide, N,N-diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-α-phenyl-;N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide;N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide;4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE;hypothalamus,JNJ-31020028,anxiety,microdialysis,depression,JNJ31020028,norepinephrine,NPY receptor,Neuropeptide Y Receptor,Inhibitor,stress-induced anorexia,inhibit
CBNumber
CB32627994
Molecular Formula
C34H36FN5O2
Formula Weight
565.68
MOL File
1094873-14-9.mol
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JNJ 31020028 Property

Boiling point:
677.5±55.0 °C(Predicted)
Density 
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
form 
Powder
pka
12.14±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
5mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
10mg
Price
$268
Updated
2024/03/01
Cayman Chemical
Product number
18407
Product name
JNJ-31020028
Purity
≥95%
Packaging
25mg
Price
$586
Updated
2024/03/01
Usbiological
Product number
474118
Product name
JNJ-31020028
Packaging
100mg
Price
$1507
Updated
2021/12/16
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JNJ 31020028 Chemical Properties,Usage,Production

Description

JNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y2 over Y1, Y4, and Y5 receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pKB = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC50 = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y2 receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.

JNJ 31020028 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ 31020028 Suppliers

China 62 India 1 United States 14 Global 77
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from JNJ 31020028 manufacturers

Career Henan Chemical Co
Product
JNJ 31020028 1094873-14-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

1094873-14-9, JNJ 31020028Related Search:

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  • JNJ 31020028
  • N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide
  • N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide
  • 4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE
  • JNJ31020028, >98%
  • JNJ-31020028?, >98%
  • CS-1745
  • JNJ-31020028;JNJ 31020028
  • 1-Piperazineacetamide, N,N-diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-α-phenyl-
  • hypothalamus,JNJ-31020028,anxiety,microdialysis,depression,JNJ31020028,norepinephrine,NPY receptor,Neuropeptide Y Receptor,Inhibitor,stress-induced anorexia,inhibit
  • 1094873-14-9
  • C34H36FN5O2
  • Inhibitors