JNJ 31020028

ChemicalBook > CAS DataBase List > JNJ 31020028

Product Name: JNJ 31020028
CAS No.: 1094873-14-9
Chemical Name: JNJ 31020028
Synonyms: CS-1745;JNJ 31020028;JNJ31020028, >98%;JNJ-31020028?, >98%;JNJ-31020028;JNJ 31020028;1-Piperazineacetamide, N,N-diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-α-phenyl-;N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide;N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide;4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE;hypothalamus,JNJ-31020028,anxiety,microdialysis,depression,JNJ31020028,norepinephrine,NPY receptor,Neuropeptide Y Receptor,Inhibitor,stress-induced anorexia,inhibit
CBNumber: CB32627994
Molecular Formula: C34H36FN5O2
Formula Weight: 565.68
MOL File: 1094873-14-9.mol

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JNJ 31020028 Property

Boiling point:: 677.5±55.0 °C(Predicted)
Density: 1.228±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
form: Powder
pka: 12.14±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18407
Product name: JNJ-31020028
Purity: ≥95%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 18407
Product name: JNJ-31020028
Purity: ≥95%
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 18407
Product name: JNJ-31020028
Purity: ≥95%
Packaging: 10mg
Price: $268
Updated: 2024/03/01

Cayman Chemical

Product number: 18407
Product name: JNJ-31020028
Purity: ≥95%
Packaging: 25mg
Price: $586
Updated: 2024/03/01

Usbiological

Product number: 474118
Product name: JNJ-31020028
Packaging: 100mg
Price: $1507
Updated: 2021/12/16

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JNJ 31020028 Chemical Properties,Usage,Production

Description

JNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y₂ (IC₅₀s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y₂ over Y₁, Y₄, and Y₅ receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pK_B = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC₅₀ = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y₂ receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.

JNJ 31020028 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JNJ 31020028 manufacturers

Career Henan Chemical Co

Product: JNJ 31020028 1094873-14-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

1094873-14-9, JNJ 31020028Related Search:

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JNJ 31020028

N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide

N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide

4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE

JNJ31020028, >98%

JNJ-31020028?, >98%

CS-1745

JNJ-31020028;JNJ 31020028

1-Piperazineacetamide, N,N-diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-α-phenyl-

hypothalamus,JNJ-31020028,anxiety,microdialysis,depression,JNJ31020028,norepinephrine,NPY receptor,Neuropeptide Y Receptor,Inhibitor,stress-induced anorexia,inhibit

1094873-14-9

C34H36FN5O2

Inhibitors