JNJ-10229570
- Product Name
- JNJ-10229570
- CAS No.
- 524923-88-4
- Chemical Name
- JNJ-10229570
- Synonyms
- JNJ-10229570;JNJ-10229571;UNII-N9IX402L35;JNJ-10229570 ，S0019;JNJ-10229570, 10 mM in DMSO;JNJ-10229570; JNJ10229570; JNJ 10229570;2,3-Bis(2-methoxyphenyl)-N-phenyl-1,2,4-thiadiazol-5(2H)-imine;JNJ-10229570,MC Receptor,Inhibitor,inhibit,Melanocortin Receptor;N-[2,3-Bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]aniline;N-[2,3-Bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]benzenamine
- CBNumber
- CB14695492
- Molecular Formula
- C22H19N3O2S
- Formula Weight
- 389.47
- MOL File
- 524923-88-4.mol
JNJ-10229570 Property
- Boiling point:
- 541.2±60.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 62.5 mg/mL (160.47 mM)
- form
- Solid
- pka
- 0.95±0.20(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- orb573015
- Product name
- JNJ-10229570
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
- Product number
- CS-0027408
- Product name
- JNJ-10229570
- Purity
- >98.0%
- Packaging
- 25mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- orb573015
- Product name
- JNJ-10229570
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1431.4
- Updated
- 2021/12/16
- Product number
- CS-0027408
- Product name
- JNJ-10229570
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $1500
- Updated
- 2021/12/16
- Product number
- CS-0027408
- Product name
- JNJ-10229570
- Purity
- >98.0%
- Packaging
- 100mg
- Price
- $2100
- Updated
- 2021/12/16
JNJ-10229570 Chemical Properties,Usage,Production
Uses
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
in vivo
Topical treatment with JNJ-10229570 of human skins transplanted onto SCID mice result in a marked decrease in sebum-specific lipid production, sebaceous gland's size and the expression of the sebaceous differentiation marker epithelial-membrane antigen (EMA). Topical treatment with 0.05% JNJ-10229570 leads to a distinct reduction in both the steady-state and the newly-synthesized sebum-specific lipids, with lesser effects on triglycerides and cholesterol[1].
References
[1] Eisinger M, et al. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32. DOI:10.1016/j.jdermsci.2011.04.001
JNJ-10229570 Preparation Products And Raw materials
Raw materials
Preparation Products
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