JNJ 63533054

Product Name: JNJ 63533054
CAS No.: 1802326-66-4
Chemical Name: JNJ 63533054
Synonyms: CS-2223;JNJ 63533054;JNJ 63533054 ，S6425;JNJ-63533054 (JNJ63533054;JNJ-63533054 >=98% (HPLC);JNJ-63533054, 10 mM in DMSO;(S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide;3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide;Benzamide, 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]-;L-tryptophan,blood-brain,oral,CNS,L-phenylalanine,G Protein-Coupled Receptor 139,barrier,JNJ63533054,Inhibitor,GPR139,JNJ-63533054,inhibit
CBNumber: CB43110757
Molecular Formula: C17H17ClN2O2
Formula Weight: 316.78
MOL File: 1802326-66-4.mol

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JNJ 63533054 Property

Boiling point:: 559.7±45.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: Soluble in DMSO (up to 35 mg/ml).
form: powder
pka: 12.77±0.46(Predicted)
color: white to beige
optical activity: [α]/D -89 to -99°, c = 1 in ethanol
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1624
Product name: JNJ-63533054
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $94.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1624
Product name: JNJ-63533054
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $380
Updated: 2025/07/31

Cayman Chemical

Product number: 23450
Product name: JNJ-63533054
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23450
Product name: JNJ-63533054
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 23450
Product name: JNJ-63533054
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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JNJ 63533054 Chemical Properties,Usage,Production

Description

JNJ-63533054 (1802326-66-4) is a potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1?Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2?Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3?Suppresses morphine intake in a mouse self-administration model.4

Uses

JNJ 63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.

Biochem/physiol Actions

JNJ-63533054 is a potent and selective agonist of the orphan receptor hGPR139, a GPCR receptor expressed in the brain in circumventricular regions of the habenula and septum. JNJ-63533054 has an EC50 value of 16 nM, crosses the blood-brain barrier, and is orally available.

in vivo

JNJ-63533054 (3-30 mg/kg; oral administration; once; SD rats) treatment induces a dose-dependent reduction in locomotor activity in the first hour^[1].
? The pharmacokinetics of JNJ-63533054 (Compound 7c; 1 mg/kg iv; 5 mg/kg po) in rat is examined. The IV clearance is 53 mL/min/kg,? the C_max is 317 ng/mL (~1 μM), the t_1/2 is 2.5 hours,? and JNJ-63533054 is able to cross the blood-brain barrier (BBB) with a brain to plasma ratio (b/p) of 1.2^[2].

Animal Model:	Male Sprague-Dawley rats (350-450 g)^[1]
Dosage:	3 mg/kg, 10 mg/kg, and 30 mg/kg
Administration:	Oral administration; once
Result:	Induced a dose-dependent reduction in locomotor activity in the first hour.

storage

Store at RT

References

[1] CURT A. DVORAK*. Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor[J]. ACS Medicinal Chemistry Letters, 2015, 6 9: 1015-1018. DOI:10.1021/acsmedchemlett.5b00247
[2] CHANGLU LIU. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.[J]. Molecular Pharmacology, 2015, 88 5: 911-925. DOI:10.1124/mol.115.100412
[3] JENNI KONONOFF. Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.[J]. eNeuro, 2018. DOI:10.1523/eneuro.0153-18.2018
[4] DANDAN WANG. Genetic behavioral screen identifies an orphan anti-opioid system[J]. Science, 2019, 365 6459. DOI:10.1126/science.aau2078

JNJ 63533054 Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ 63533054 Suppliers

China 68 India 1 United Kingdom 1 United States 12 Global 82

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
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Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
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Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
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Sigma-Aldrich

Tel: 021-61415566 800-8193336
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Shanghai Lollane Biological Technology Co.,Ltd.

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D&C Chemicals

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ShangHai Siyan Biological Technology Co., Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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View Lastest Price from JNJ 63533054 manufacturers

Career Henan Chemical Co

Product: JNJ 63533054 1802326-66-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

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JNJ 63533054

3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide

CS-2223

JNJ-63533054 (JNJ63533054

Benzamide, 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]-

JNJ-63533054 >=98% (HPLC)

(S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide

L-tryptophan,blood-brain,oral,CNS,L-phenylalanine,G Protein-Coupled Receptor 139,barrier,JNJ63533054,Inhibitor,GPR139,JNJ-63533054,inhibit

JNJ-63533054, 10 mM in DMSO

JNJ 63533054 ，S6425

1802326-66-4