EPPTB

Product Name: EPPTB
CAS No.: 1110781-88-8
Chemical Name: EPPTB
Synonyms: EPPTB;RO5212773);EPPTB (RO 5212773;Ro 5212773 (EPPTB);EPPTB, TAAR1 antagonist;Ro 5212773, 10 mM in DMSO;N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide;N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide;Benzamide, N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)-;Ro-5212773,Inhibitor,Ro 5212773,neuronal,inhibit,Ro5212773,mesolimbic,system,TAAR1,GPCR
CBNumber: CB13146292
Molecular Formula: C20H21F3N2O2
Formula Weight: 378.39
MOL File: 1110781-88-8.mol

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EPPTB Property

storage temp.: -20°C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1350
Product name: EPPTB
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $103
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1350
Product name: EPPTB
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $404
Updated: 2025/07/31

Tocris

Product number: 4518
Product name: EPPTB
Purity: ≥99%(HPLC)
Packaging: 10
Price: $168
Updated: 2021/12/16

Tocris

Product number: 4518
Product name: EPPTB
Purity: ≥99%(HPLC)
Packaging: 50
Price: $699
Updated: 2021/12/16

Usbiological

Product number: 255257
Product name: EPPTB
Packaging: 10mg
Price: $409
Updated: 2021/12/16

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EPPTB Chemical Properties,Usage,Production

Description

EPPTB (1110781-88-8) is a novel selective trace amine associated receptor 1 (TAAR1) antagonist (IC50=28 nM at mouse TAAR1).1,2 A useful tool for probing the physiologic role of TAAR1.3-6

Uses

EPPTB is a selective antagonist of the trace amine-associated 1 (TA1) receptor, increasing the firing frequency of dopamine (DA) neurons in the ventral tegmental area. This makes it a promising drug target for neurodegenerative disorders.

storage

Store at +4°C

References

[1] AMYAOUCH BRADAIA. The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 47: 20081-20086. DOI:10.1073/pnas.0906522106
[2] HENRI STALDER Roger D N Marius C Hoener. Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773)[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21 4: Pages 1227-1231. DOI:10.1016/j.bmcl.2010.12.075
[3] XIAOQUN ZHANG. Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine.[J]. Frontiers in Pharmacology, 2018: 166. DOI:10.3389/fphar.2018.00166
[4] DANILO DE GREGORIO . The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors[J]. Pharmacological research, 2016, 113: Pages 81-91. DOI:10.1016/j.phrs.2016.08.022
[5] ELENA CICHERO. Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach[J]. Chemical Biology & Drug Design, 2014, 84 6: 712-720. DOI:10.1111/cbdd.12367
[6] XUEHONG LIU A J David K Grandy. Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1.[J]. Journal of Pharmacology and Experimental Therapeutics, 2014, 350 1: 124-129. DOI:10.1124/jpet.114.213116

EPPTB Preparation Products And Raw materials

Raw materials

Preparation Products

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EPPTB Suppliers

China 38 India 1 United Kingdom 1 United States 9 USA 1 Global 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1010
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 18130062233
Email: 3362556465@qq.com
Country: China
ProdList: 8100
Advantage: 58

1110781-88-8, EPPTBRelated Search:

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EPPTB

N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide

EPPTB (RO 5212773

RO5212773)

N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide

Benzamide, N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)-

Ro 5212773 (EPPTB)

Ro-5212773,Inhibitor,Ro 5212773,neuronal,inhibit,Ro5212773,mesolimbic,system,TAAR1,GPCR

EPPTB, TAAR1 antagonist

Ro 5212773, 10 mM in DMSO

1110781-88-8