JNJ-7706621

Product Name: JNJ-7706621
CAS No.: 443797-96-4
Chemical Name: JNJ-7706621
Synonyms: CS-409;JNJ-7706621 USP/EP/BP;JNJ7706621; JNJ 7706621;Aurora Kinase/Cdk Inhibitor;JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor;Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide;4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide;Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-;Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase
CBNumber: CB62484646
Molecular Formula: C15H12F2N6O3S
Formula Weight: 394.36
MOL File: 443797-96-4.mol

More

Less

JNJ-7706621 Property

Melting point:: 149-155℃
Boiling point:: 676.6±65.0 °C(Predicted)
Density: 1.71
storage temp.: +2C to +8C
solubility: Soluble in DMSO at 15mg/ml
form: White solid
pka: 9.80±0.12(Predicted)
color: White to off-white
Sensitive: Light Sensitive

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 189406
Product name: Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
Packaging: 5mg
Price: $403
Updated: 2024/03/01

Alfa Aesar

Product number: J65997
Product name: Aurora Kinase/Cdk Inhibitor
Packaging: 5mg
Price: $379
Updated: 2023/06/20

Cayman Chemical

Product number: 18494
Product name: JNJ-7706621
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18494
Product name: JNJ-7706621
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18494
Product name: JNJ-7706621
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

More

Less

JNJ-7706621 Chemical Properties,Usage,Production

Description

JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC₅₀s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity for these enzymes over a panel of other receptors and kinases, although it exhibits submicromolar inhibition of VEGF and FGF receptors, as well as GSK3β. JNJ-7706621 blocks the growth of a large variety of cancer cell lines (IC₅₀ values range from 112 to 514 nM), with lower potency against normal cells (IC₅₀ values between 3.67 and 5.42 μM). It induces the regression of A375 melanoma human tumor xenografts in mice. JNJ-7706621 is a substrate for the ATP-binding cassette transporter G2, also known as breast cancer resistance protein.

Uses

JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing''s sarcoma.

Definition

ChEBI: 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide is a sulfonamide.

target

CDK1

JNJ-7706621 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

JNJ-7706621 Suppliers

China 97 Germany 1 India 2 United Kingdom 1 United States 20 Global 121

CAREBIO PHARMA

Tel: 18501057619
Email: 771737847@qq.com
Country: China
ProdList: 114
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Xi’an chemsoar Medical Technology Co., ltd

Tel: 029-86538357
Fax: 029-87871708
Country: China
ProdList: 234
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

443797-96-4, JNJ-7706621Related Search:

JNJ0966 JNJ-38158471 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine TRC253 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine JNJ 63533054 JNJ-26481585 N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide JNJ 31020028 JNJ-10229570 JNJ-632 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide ZM 447439 Ribociclib Orantinib (SU6668) BI-D1870 CCT129202 AT9283

4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide JNJ7706621

4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide

Aurora Kinase/Cdk Inhibitor

Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

CS-409

JNJ7706621; JNJ 7706621

Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-

4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide

JNJ-7706621 USP/EP/BP

JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor

Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase

443797-96-4

C15H12F2N6O3S

Inhibitor

Inhibitors