N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Product Name
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- CAS No.
- 315703-52-7
- Chemical Name
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Synonyms
- JK 184;CS-2369;JK184 (JK-184;Hh Signaling Antagonist VII;Hh Signaling Antagonist VII, JK184;JK 184;JK-184;HH SIGNALING ANTAGONIST VII;JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- CBNumber
- CB02485085
- Molecular Formula
- C19H18N4OS
- Formula Weight
- 350.44
- MOL File
- 315703-52-7.mol
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Property
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- off-white to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 373385
- Product name
- Hh Signaling Antagonist VII, JK184
- Packaging
- 5mg
- Price
- $140
- Updated
- 2023/01/07
- Product number
- 15265
- Product name
- JK 184
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15265
- Product name
- JK 184
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- J4205
- Product name
- JK184
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $314
- Updated
- 2022/05/15
- Product number
- 15265
- Product name
- JK 184
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Chemical Properties,Usage,Production
Uses
JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
Uses
JK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.
Biological Activity
Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .
storage
+4°C
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine manufacturers
- Product
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine 315703-52-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25