N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Product Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
CAS No.: 315703-52-7
Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
Synonyms: JK 184;CS-2369;JK184 (JK-184;Hh Signaling Antagonist VII;Hh Signaling Antagonist VII, JK184;JK 184;JK-184;HH SIGNALING ANTAGONIST VII;JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
CBNumber: CB02485085
Molecular Formula: C19H18N4OS
Formula Weight: 350.44
MOL File: 315703-52-7.mol

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Property

storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
color: off-white to light brown

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 373385
Product name: Hh Signaling Antagonist VII, JK184
Packaging: 5mg
Price: $140
Updated: 2023/01/07

Cayman Chemical

Product number: 15265
Product name: JK 184
Purity: ≥99%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15265
Product name: JK 184
Purity: ≥99%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Sigma-Aldrich

Product number: J4205
Product name: JK184
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $314
Updated: 2022/05/15

Cayman Chemical

Product number: 15265
Product name: JK 184
Purity: ≥99%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Chemical Properties,Usage,Production

Uses

JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]

Uses

JK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.

Biological Activity

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .

storage

+4°C

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Suppliers

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View Lastest Price from N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine manufacturers

Career Henan Chemical Co

Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine 315703-52-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

315703-52-7, N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amineRelated Search:

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Hh Signaling Antagonist VII, JK184

JK 184

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

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Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

CS-2369

JK184 (JK-184

Hh Signaling Antagonist VII

JK 184;JK-184;HH SIGNALING ANTAGONIST VII

JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog

315703-52-7