BIX 02188

Product Name: BIX 02188
CAS No.: 1094614-84-2
Chemical Name: BIX 02188
Synonyms: CS-38;BIX 02188;(E/Z)-BIX02188;BIX 02188, >=98%;BIX 02188 USP/EP/BP;BIX 02188(BIX-02188;BIX 02188(BIX-02188;BIX02188);BIX-02188(Random Configuration);BIX-02188 BIX02188MEK5 inhibitor potent and selective;3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
CBNumber: CB02489917
Molecular Formula: C25H24N4O2
Formula Weight: 412.48366
MOL File: 1094614-84-2.mol

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BIX 02188 Property

Melting point:: >268oC (dec.)
Boiling point:: 615.8±55.0 °C(Predicted)
Density: 1.283
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 11.19±0.20(Predicted)
color: Yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B591685
Product name: BIX02188
Packaging: 10mg
Price: $150
Updated: 2021/12/16

Usbiological

Product number: 162918
Product name: BIX02188
Packaging: 10mg
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000917
Product name: 3-[[[3-[(DIMETHYLAMINO)METHYL]PHENYL]AMINO]PHENYLMETHYLENE]-2,3-DIHYDRO-2-OXO-1H-INDOLE-6-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $496.31
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb154720
Product name: BIX02188 (BIX 02188)
Purity: >98%
Packaging: 100mg
Price: $765
Updated: 2021/12/16

AK Scientific

Product number: X7394
Product name: (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
Packaging: 50mg
Price: $876
Updated: 2021/12/16

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BIX 02188 Chemical Properties,Usage,Production

Uses

BIX02188 MEK inhibitor, prevents cell proliferation and induces apoptosis. Can be applied towards treatments of cancers and proliferative cell diseases.

Biological Activity

bix 02188 is a selective inhibitor of mek5 with ic50 value of 4.3 nm 1.bix 02188 belongs to the indolinone kinase inhibitor series. it selectively inhibited the catalytic activity of mek5 but not other closely related kinases such as mek1, mek2, erk2 and jnk2. bix 02188 also inhibited erk5 with ic50 value of 810 nm. in hela cells, treatment of bix 02188 inhibited the phosphorylation of erk5 but not erk1/2. besides that, bix 02188 prevented the transcription of the downstream substrate mef2c in hela and hek293 cells. when tested with a panel of 79 kinases, bix 02188 showed some degree of inhibition of the kinases csf1r, kit and lck with ic50 values of 280 nm, 550 nm and 390 nm, respectively 1.

target

MEK5

References

1. tatake r j, o’neill m m, kennedy c a, et al. identification of pharmacological inhibitors of the mek5/erk5 pathway. biochemical and biophysical research communications, 2008, 377(1): 120-125.

BIX 02188 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX 02188 Suppliers

Canada 1 China 89 India 2 United Kingdom 1 United States 12 Global 105

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ShangHai YingYi Chemical Technology Co., Ltd.

Tel: 86-21-50700185 13764109623
Fax: 86-21-50700185
Email: sale@inyelchem.com
Country: China
ProdList: 178
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Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

1094614-84-2, BIX 02188Related Search:

Selumetinib MK-2206 2HCl Enzalutamide BIX 02189 Carfilzomib Olaparib

3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

BIX 02188

BIX 02188(BIX-02188

BIX 02188(BIX-02188;BIX02188)

BIX-02188(Random Configuration)

(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide

3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide BIX 02188

BIX 02188, >=98%

CS-38

3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide

BIX 02188 USP/EP/BP

(E/Z)-BIX02188

BIX-02188 BIX02188MEK5 inhibitor potent and selective

1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-

1094614-84-2

Inhibitors

MAPK