Description
ChemicalBook > CAS DataBase List > Foretinib (GSK1363089)

Foretinib (GSK1363089)

Description
Product Name
Foretinib (GSK1363089)
CAS No.
849217-64-7
Chemical Name
Foretinib (GSK1363089)
Synonyms
Foretinib;XL880;EXEL-2880;GSK089;GSK 1363089;XL-880,Foretinib;EXEL-2880/XL-880;Foretinib, >=98%;XL880(GSK1363089);Foretinib (XL-880)
CBNumber
CB02490083
Molecular Formula
C34H34F2N4O6
Formula Weight
632.65
MOL File
849217-64-7.mol
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Foretinib (GSK1363089) Property

Melting point:
>98°C (dec.)
Boiling point:
828.5±65.0 °C(Predicted)
Density 
1.372
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Ethanol (Slightly)
pka
13.14±0.70(Predicted)
form 
Yellow powder.
color 
Pale Yellow to Yellow
CAS DataBase Reference
849217-64-7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16249
Product name
Foretinib
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16249
Product name
Foretinib
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
16249
Product name
Foretinib
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
16249
Product name
Foretinib
Purity
≥98%
Packaging
25mg
Price
$230
Updated
2024/03/01
Tocris
Product number
6056
Product name
GSK1363089
Purity
≥98%(HPLC)
Packaging
10
Price
$177
Updated
2021/12/16
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Foretinib (GSK1363089) Chemical Properties,Usage,Production

Description

Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

Description

Foretinib is a multikinase inhibitor that targets MET and VEGFR2 and also exhibits an inhibitory effect against KIT, Flt-3, PDGFRb, and Tie-2.

Uses

XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively.

Uses

Foretinib (GSK1363089) is an ATP-competitive inhibitor of hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF) Receptor Tyrosine Kinases.

Definition

ChEBI: N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide is an aromatic ether.

Clinical Use

Foretinib has also shown to be effective against ROS1 mutations especially when acquired with crizotinib resistance. A clinical trial investigating the dosing and safety profile of combining foretinib and erlotinib was designed for advanced pretreated NSCLC patients.

in vitro

In vitro, foretinib blocks activation of MET and VEGFR2-induced signaling pathways. In vivo experiments show a dose-dependent decrease in tumor burden in a lung metastasis experimental model.

target

Met

References

[1] qian f1, engst s, yamaguchi k, yu p, won ka, mock l, lou t, tan j, li c, tam d, lougheed j, yakes fm, bentzien f, xu w, zaks t, wooster r,greshock j, joly ah. inhibition of tumor cell growth, invasion, and metastasis by exel-2880 (xl880, gsk1363089), a novel inhibitor of hgf and vegf receptor tyrosine kinases. cancer res. 2009 oct 15;69(20):8009-16. doi: 10.1158/0008-5472.can-08-4889.

Foretinib (GSK1363089) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Foretinib (GSK1363089) manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Foretinib (GSK1363089) 849217-64-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
Foretinib (GSK1363089) 849217-64-7
Price
US $2.00/kg
Min. Order
1 kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

849217-64-7, Foretinib (GSK1363089)Related Search:


  • Foretinib
  • GSK 1363089
  • EXEL-2880
  • XL880
  • N-[3-Fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
  • XL-880,Foretinib
  • XL880(GSK1363089)
  • FORETINIB GLAXOSMITHKLINE PAPILLARY RENAL CELL CARCINOMA PHASE IIRSCH. TRIANGLE PARK, NC (SEE ALSO HEAD/NECK) (888) 825-5249
  • foretinib N1-{3-fluoro-4-[(6-(Methyloxy)-7-{[3-(4-Morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide
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  • GSK089
  • GSK1363089; FORETINIB; EXEL-2880
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  • EXEL-2880/XL-880
  • N-(3-fluoro-4-(6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxaMide
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  • 1-N'-[3-FLUORO-4-({6-METHOXY-7-[3-(MORPHOLIN-4-YL)PROPOXY]QUINOLIN-4-YL}OXY)PHENYL]-1-N-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE
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  • 849217-64-7
  • C34H34F2N4O6
  • Inhibitors