XL-388

Product Name: XL-388
CAS No.: 1251156-08-7
Chemical Name: XL-388
Synonyms: XL388;XL-388;CS-772;XL 388;XL388, >=98%;XL-388;XL 388;XL-388 USP/EP/BP;XL388, 10 mM in DMSO;Carbamazepine 298-46-4 three units, HPLC Purity : XL388;inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388
CBNumber: CB32666702
Molecular Formula: C23H22FN3O4S
Formula Weight: 455.5
MOL File: 1251156-08-7.mol

More

Less

XL-388 Property

Melting point:: >188oC (dec.)
Boiling point:: 738.6±60.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 6.22±0.13(Predicted)
form: Solid
color: Off-White to Pale Yellow
Stability:: Hygroscopic

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1239
Product name: XL388
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $58.4
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 25mg
Price: $505
Updated: 2024/03/01

Cayman Chemical

Product number: 20237
Product name: XL388
Purity: ≥98%
Packaging: 50mg
Price: $903
Updated: 2024/03/01

More

Less

XL-388 Chemical Properties,Usage,Production

Uses

XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.

Biological Activity

XL388 is a potent, selective, orally bioavailable ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) with an IC50 of 9.9 nM for mTOR, 8 nM for mTORC1, 166 nM for mTORC2, and 1000-fold selectivity for mTOR over the closely related PI3K kinases and a panel of 141 protein kinases tested. XL388 blocked mTORC1 phosphorylation of p70S6K (T389) with an IC50 value of 94 nM and blocked mTORC2 phosphorylationof AKT (S473) with an IC50 value of 350 nM. XL388 showed complete tumor growth inhibition in mice bearing MCF-7 xenograft tumors.

XL-388 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

XL-388 Suppliers

China 76 India 2 United Kingdom 2 United States 17 Global 97

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9478
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18021050169
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

1251156-08-7, XL-388Related Search:

XL-765,SAR245409 Foretinib (GSK1363089) 5-Bromo-4-chloro-3-indolyl-beta-D-galactoside XL147 1,1-Cyclopropanedicarboxamide, N-(4-fluorophenyl)-N'-[4-[[7-methoxy-6-[(methylamino)carbonyl]-4-quinolinyl]oxy]phenyl]- 4-Cyanopyridine 2-Amino-4-(trifluoromethyl)pyridine DI-2-PYRIDYL KETONE XL413 (BMS-863233) BMS-852927 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate XL888 XL019 XL 228 AZD-8055 OSI-027 Cediranib Ribociclib

Methanone, [7-(6-amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-

[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone XL388

XL388, >=98%

(7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methy

XL 388

XL388

XL-388

[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone

Carbamazepine 298-46-4 three units, HPLC Purity : XL388

XL-388;XL 388

CS-772

XL-388 USP/EP/BP

(7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone

inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388

XL388, 10 mM in DMSO

1251156-08-7

PI3K/Akt/mTOR

Akt

mTOR

PI3K

Inhibitors