ChemicalBook > CAS DataBase List > 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate

2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate

Product Name
2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate
CAS No.
1224964-36-6
Chemical Name
2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate
Synonyms
XL-784;XL 784,XL784;2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate
CBNumber
CB83361487
Molecular Formula
C21H22ClF2N3O8S
Formula Weight
549.9294864
MOL File
1224964-36-6.mol
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2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Property

storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 110 mg/mL (200.39 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0015584
Product name
XL-784
Purity
98.20%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0015584
Product name
XL-784
Purity
98.20%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0015584
Product name
XL-784
Purity
98.20%
Packaging
25mg
Price
$990
Updated
2021/12/16
ChemScene
Product number
CS-0015584
Product name
XL-784
Purity
98.20%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0015584
Product name
XL-784
Purity
98.20%
Packaging
100mg
Price
$2500
Updated
2021/12/16
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2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Uses

XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

in vivo

All mice tolerate the treatments similarly. Control mice all developed aneurysms with a mean %△AD of 158.5%±4.3%. Treatment with all doses of XL-784 and doxycycline are effective in inhibiting aortic dilatation. There is a clear dose-response relationship between XL-784 and reductions in aortic dilatation at harvest (50 mg/kg 140.4% ±3.2%; 125 mg/kg 129.3% ±5.1%; 250 mg/kg 119.2%±3.5%; all Ps<0.01 compared to control). This continues with the higher doses (375 mg/kg 88.6%±4.4%; 500 mg/kg 76.0%±3.5%). The highest 2 doses of XL-784 tested are more effective than doxycycline (112.2%±2.0%, P<0.05) in inhibiting maximal dilatation of the aorta after elastase perfusion[2].

IC 50

MMP-2: 0.81 nM (IC50); MMP13: 0.56 nM (IC50); MMP-8: 10.8 nM (IC50); MMP-9: 18 nM (IC50); MMP-3: 120 nM (IC50); MMP-1: 1900 nM (IC50)

References

[1] Williams JM, et al. Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. Am J Physiol Renal Physiol. 2011 Apr;300(4):F983-98. DOI:10.1152/ajprenal.00262.2010
[2] Ennis T, et al. Effect of novel limited-spectrum MMP inhibitor XL784 in abdominal aortic aneurysms. J Cardiovasc Pharmacol Ther. 2012 Dec;17(4):417-26. DOI:10.1177/1074248412455695

2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate Suppliers

China 13 United States 3 Global 16
Suzhou Chukai PharmaTech
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1224964-36-6, 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylateRelated Search:

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  • 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate
  • XL-784
  • XL 784,XL784
  • 1224964-36-6