XL413 (hydrochloride)

Product Name: XL413 (hydrochloride)
CAS No.: 2062200-97-7
Chemical Name: XL413 (hydrochloride)
Synonyms: XL413 xhydrochloride;XL413 hydrochloride, 10 mM in DMSO;XL-413 hydrochloride,XL413 hydrochloride
CBNumber: CB14666854
Molecular Formula: C14H13Cl2N3O2
Formula Weight: 326.18
MOL File: 2062200-97-7.mol

More

Less

XL413 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM)
form: A crystalline solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 24906
Product name: XL413 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Cayman Chemical

Product number: 24906
Product name: XL413 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 24906
Product name: XL413 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $444
Updated: 2024/03/01

Cayman Chemical

Product number: 24906
Product name: XL413 (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $748
Updated: 2023/06/20

ChemScene

Product number: CS-1957
Product name: XL413 hydrochloride
Purity: 99.72%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

More

Less

XL413 (hydrochloride) Chemical Properties,Usage,Production

Description

XL413 is a potent inhibitor of Cdc7 (IC₅₀ = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC₅₀s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G₂ phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED₅₀ = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.

Uses

XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.

in vivo

XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss^[1].

IC 50

Cdc7: 3.4 nM (IC₅₀); PIM1: 42 nM (IC₅₀); CK2: 215 nM (IC₅₀)

References

[1] Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. DOI:10.1016/j.bmcl.2012.04.024
[2] Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300. DOI:10.1371/journal.pone.0113300

XL413 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

XL413 (hydrochloride) Suppliers

China 20 United States 4 Global 24

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9751
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4181
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

2062200-97-7, XL413 (hydrochloride)Related Search:

XL 228 XL-019 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- XL-388 BMS-908662 XL888 XL765 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate

XL-413 hydrochloride,XL413 hydrochloride

XL413 xhydrochloride

XL413 hydrochloride, 10 mM in DMSO

2062200-97-7