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XL413 (hydrochloride)

Product Name
XL413 (hydrochloride)
CAS No.
2062200-97-7
Chemical Name
XL413 (hydrochloride)
Synonyms
XL-413 hydrochloride,XL413 hydrochloride
CBNumber
CB14666854
Molecular Formula
C14H13Cl2N3O2
Formula Weight
326.18
MOL File
2062200-97-7.mol
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XL413 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM)
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24906
Product name
XL413 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$119
Updated
2024/03/01
Cayman Chemical
Product number
24906
Product name
XL413 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$223
Updated
2024/03/01
Cayman Chemical
Product number
24906
Product name
XL413 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$444
Updated
2024/03/01
Cayman Chemical
Product number
24906
Product name
XL413 (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$748
Updated
2023/06/20
ChemScene
Product number
CS-1957
Product name
XL413 hydrochloride
Purity
99.72%
Packaging
100mg
Price
$900
Updated
2021/12/16
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XL413 (hydrochloride) Chemical Properties,Usage,Production

Description

XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.

XL413 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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XL413 (hydrochloride) Suppliers

China 12 United States 3 Global 15
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4393
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24023
Advantage
58

2062200-97-7, XL413 (hydrochloride)Related Search:


  • XL-413 hydrochloride,XL413 hydrochloride
  • 2062200-97-7