BMS-908662

Product Name: BMS-908662
CAS No.: 870603-16-0
Chemical Name: BMS-908662
Synonyms: BMS-908662;BMS-908662(1X-281);Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester
CBNumber: CB34919927
Molecular Formula: C24H19ClN4O4
Formula Weight: 462.89
MOL File: 870603-16-0.mol

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BMS-908662 Property

Density: 1.526±0.06 g/cm3(Predicted)
pka: 10.77±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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BMS-908662 Chemical Properties,Usage,Production

Uses

XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1].

IC 50

c-Raf: 2.6 nM (IC₅₀); B-Raf: 4.5 nM (IC₅₀); B-Raf^V600E: 6 nM (IC₅₀)

References

[1] Dickson MA, et al., Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):349-56. DOI:10.1007/s10637-014-0191-5

BMS-908662 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-908662 Suppliers

China 7 United States 2 Global 9

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870603-16-0, BMS-908662Related Search:

XL 228 XL-019 XL413 (hydrochloride) 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- XL-388 XL888 XL765 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate

BMS-908662

Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester

BMS-908662(1X-281)

870603-16-0