ChemicalBook > CAS DataBase List > XL-388

XL-388

Product Name
XL-388
CAS No.
1251156-08-7
Chemical Name
XL-388
Synonyms
XL388;XL-388;CS-772;XL 388;XL388, >=98%;XL-388;XL 388;XL-388 USP/EP/BP;XL388, 10 mM in DMSO;Carbamazepine 298-46-4 three units, HPLC Purity : XL388;inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388
CBNumber
CB32666702
Molecular Formula
C23H22FN3O4S
Formula Weight
455.5
MOL File
1251156-08-7.mol
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XL-388 Property

Melting point:
>188oC (dec.)
Boiling point:
738.6±60.0 °C(Predicted)
Density 
1.354±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
6.22±0.13(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1239
Product name
XL388
Purity
≥98% (HPLC)
Packaging
5MG
Price
$58.4
Updated
2024/03/01
Cayman Chemical
Product number
20237
Product name
XL388
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
20237
Product name
XL388
Purity
≥98%
Packaging
10mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
20237
Product name
XL388
Purity
≥98%
Packaging
25mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
20237
Product name
XL388
Purity
≥98%
Packaging
50mg
Price
$903
Updated
2024/03/01
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XL-388 Chemical Properties,Usage,Production

Uses

XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.

Biological Activity

XL388 is a potent, selective, orally bioavailable ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) with an IC50 of 9.9 nM for mTOR, 8 nM for mTORC1, 166 nM for mTORC2, and 1000-fold selectivity for mTOR over the closely related PI3K kinases and a panel of 141 protein kinases tested. XL388 blocked mTORC1 phosphorylation of p70S6K (T389) with an IC50 value of 94 nM and blocked mTORC2 phosphorylationof AKT (S473) with an IC50 value of 350 nM. XL388 showed complete tumor growth inhibition in mice bearing MCF-7 xenograft tumors.

XL-388 Preparation Products And Raw materials

Raw materials

Preparation Products

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XL-388 Suppliers

China 80 India 2 United Kingdom 2 United States 17 Global 101
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1251156-08-7, XL-388Related Search:

XL-765,SAR245409 Foretinib (GSK1363089) 5-Bromo-4-chloro-3-indolyl-beta-D-galactoside XL147 1,1-Cyclopropanedicarboxamide, N-(4-fluorophenyl)-N'-[4-[[7-methoxy-6-[(methylamino)carbonyl]-4-quinolinyl]oxy]phenyl]- 4-Cyanopyridine 2-Amino-4-(trifluoromethyl)pyridine DI-2-PYRIDYL KETONE XL413 (BMS-863233) BMS-852927 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate XL888 XL019 XL 228 AZD-8055 OSI-027 Cediranib Ribociclib

  • Methanone, [7-(6-amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-
  • [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone XL388
  • XL388, >=98%
  • (7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methy
  • XL 388
  • XL388
  • XL-388
  • [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
  • Carbamazepine 298-46-4 three units, HPLC Purity : XL388
  • XL-388;XL 388
  • CS-772
  • XL-388 USP/EP/BP
  • (7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone
  • inhibit,XL388,XL 388,Mammalian target of Rapamycin,Inhibitor,mTOR,XL-388
  • XL388, 10 mM in DMSO
  • 1251156-08-7
  • PI3K/Akt/mTOR
  • Akt
  • mTOR
  • PI3K
  • Inhibitors