ChemicalBook > CAS DataBase List > 3-Chloro-4-trifluoromethylphenol
3-Chloro-4-trifluoromethylphenol
- Product Name
- 3-Chloro-4-trifluoromethylphenol
- CAS No.
- 37900-81-5
- Chemical Name
- 3-Chloro-4-trifluoromethylphenol
- Synonyms
- 3-Chloro-4-trifluoromethylphenol;Phenol, 3-chloro-4-(trifluoromethyl)-
- CBNumber
- CB02491484
- Molecular Formula
- C7H4ClF3O
- Formula Weight
- 196.55
- MOL File
- 37900-81-5.mol
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3-Chloro-4-trifluoromethylphenol Property
- Boiling point:
- 230.2±35.0 °C(Predicted)
- Density
- 1.474±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.60±0.18(Predicted)
- form
- fused solid
- color
- White
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Safety
- HS Code
- 2908990000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
TRC
- Product number
- C598150
- Product name
- 3-Chloro-4-(trifluoromethyl)phenol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC500172
- Product name
- 3-Chloro-4-(trifluoromethyl)phenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC500172
- Product name
- 3-Chloro-4-(trifluoromethyl)phenol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2801-7-17
- Product name
- 3-Chloro-4-(trifluoromethyl)phenol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $77
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2801-7-17
- Product name
- 3-Chloro-4-(trifluoromethyl)phenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $167
- Updated
- 2021/12/16
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3-Chloro-4-trifluoromethylphenol Chemical Properties,Usage,Production
Synthesis
94444-58-3
37900-81-5
The general procedure for the synthesis of 3-chloro-4-trifluoromethylphenol from 2-chloro-4-fluorobenzotrifluoride was as follows: to a stirred solution of 2-chloro-4-fluorobenzotrifluoride (500 mg, 2.52 mmol) in anhydrous N,N-dimethylformamide (10 mL) was added 2-(trimethylmethylsilyl)ethanol (0.40 mL, 2.77 mmol), and the reaction mixture was cooled to 0 °C. Subsequently, sodium hydride (302 mg, 60% w/w oil dispersion, 7.55 mmol) was added in batches. after 5 min, the reaction mixture formed a thick white suspension. The reaction mixture was slowly warmed to room temperature and stirring was continued for 16 hr. Upon completion of the reaction, the reaction was quenched with ice water (50 mL) and washed with ether (50 mL). The aqueous phase was acidified with 2 M aqueous hydrochloric acid and subsequently extracted with ether (2 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated in vacuum for 16 h to give 3-chloro-4-trifluoromethylphenol as a yellow oil (356 mg, 72% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.75 (dd, 1H), 6.95 (d, 1H), 7.51 (d, 1H).LCMS analysis showed a retention time of Rt = 1.23 min and a mass spectrum m/z 195 [MH]-.
References
[1] Patent: WO2012/7868, 2012, A2. Location in patent: Page/Page column 73-74
[2] Patent: US2012/10207, 2012, A1
3-Chloro-4-trifluoromethylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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