BROMOHEXINE

Product Name: BROMOHEXINE
CAS No.: 3572-43-8
Chemical Name: BROMOHEXINE
Synonyms: bromhexine;BroMhexine IMpurity E;Auxit;Na 274;Bromexine;Aids001646;Aids-001646;BROMOHEXINE;AKOS B015997;AURORA KA-7546
CBNumber: CB0249452
Molecular Formula: C14H20Br2N2
Formula Weight: 376.13
MOL File: 3572-43-8.mol

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BROMOHEXINE Property

Melting point:: 238℃
Boiling point:: 413.8±40.0 °C(Predicted)
Density: 1.57
storage temp.: 2-8°C(protect from light)
solubility: DMSO: 75 mg/mL (199.40 mM);Ethanol: 75 mg/mL (199.40 mM)
pka: 8.34±0.20(Predicted)
Water Solubility: Water: Insoluble

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Safety

Toxicity: Approx LD50 orally in rabbits: >10 g/kg (Boyd, Sheppard)

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Hazard and Precautionary Statements (GHS)

Signal word: Warning

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0007117
Product name: N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE
Purity: 95.00%
Packaging: 1G
Price: $477.38
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0027098
Product name: BROMHEXINE IMPURITY E
Purity: 95.00%
Packaging: 5MG
Price: $502.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007117
Product name: N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE
Purity: 95.00%
Packaging: 25G
Price: $1422.46
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007117
Product name: N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE
Purity: 95.00%
Packaging: 50G
Price: $2392.25
Updated: 2021/12/16

Chemenu

Product number: CM201336
Product name: 2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline
Purity: 95%
Packaging: 1g
Price: $580
Updated: 2021/12/16

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BROMOHEXINE Chemical Properties,Usage,Production

Originator

Bisolvon,Boehringer Ingelheim,Switz.,1963

Uses

Expectorant; mucolytic.

Definition

ChEBI: A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive ough (i.e. a cough characterised by the production of sputum).

Manufacturing Process

In initial steps, 2-nitrobenzylbromide and cyclohexylmethylamine are reacted and that initial product reacted with hydrazine to give N-(2-aminobenzyl)-Nmethyl- cyclohexylamine.
A solution of 29.3 g of bromine in 50 cc of glacial acetic acid was slowly added dropwise to a solution of 159 g of N-(2-aminobenzyl)-N-methylcyclohexylamine, accompanied by stirring. The glacial acetic acid was decanted from the precipitate formed during the addition of the bromine solution, and the precipitate was thereafter shaken with 200 cc of 2N sodium hydroxide and 600cc of chloroform until all of the solids went into solution. The chloroform phase was allowed to separate from the aqueous phase. The chloroform phase was decanted, evaporated to dryness and the residue was dissolved in absolute ether. The resulting solution was found to be a solution of N-(2-amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine in ethanol. Upon introducing hydrogen chloride into this solution, the hydrochloride of N-(2- amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine precipitated out. It had a melting point of 232°-235°C (decomposition).

Therapeutic Function

Expectorant; Mucolytic

BROMOHEXINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BROMOHEXINE Suppliers

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View Lastest Price from BROMOHEXINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Bromhexine 3572-43-8
Price: US $0.01-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-04-24

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Bromhexine 3572-43-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-04-29

Guangzhou PI PI BIOTECH INC

Product: Bromhexine 3572-43-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-09-04

3572-43-8, BROMOHEXINERelated Search:

GERMANIUM DIBROMIDE EUROPIUM(III) BROMIDE HYDRATE 99.99+ % Methimazole Bumetanide Sodium chloride Potassium chloride Ammonium chloride Glutathione 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol S-Carboxymethyl-L-cysteine PotassiuM sodiuM Dehydroandrographolide Succinate Bromobenzene BROMHEXINE HYDROCHLORIDE FOR INJECTION BROMOHEXINE adamexine BROMOHEXINE HYDROCHLORIDE Brovanexine CISTINEXINE Bromhexine

AKOS B015997

BROMOHEXINE

AURORA KA-7546

ART-CHEM-BB B015997

Auxit

32184-12-6 (X Hydrochloride)

611-75-6 (Hydrochloride)

Aids001646

Aids-001646

BroMhexine IMpurity E

BROMHEXINE, PHARMA

2,4-Dibromo-6-((cyclohexyl(methyl)

N-2-AMINO-3,5-DIBROMOBENZYL-N-CYCLOHEXYLMETHYLAMINE

2,4-Dibromo-6-([cyclohexyl(methyl)amino]methyl)aniline

2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine

2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemathanamine

Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-

Bromexine

bromhexine

Na 274

Toluene-alpha,2-diamine, 3,5-dibromo-Nalpha-cyclohexyl-Nalpha-methyl-

N-(2-amino-3,5-dibromobenzyl)-N-cyclohexyl-N-methylamine

BROMOHEXINE USP/EP/BP

Bromhexine HCL Base

3572-43-8

208538-73-3

C14H20Br2N2