Xamoterol hemifumarate
- Product Name
- Xamoterol hemifumarate
- CAS No.
- 73210-73-8
- Chemical Name
- Xamoterol hemifumarate
- Synonyms
- Carwin;Corwin;Xamtol;XAMOTEROL;ICI-118587;Corwin：Xamtol;Xamoterol hemifumara;Alfuzosin Impurity 9;XAMOTEROL HEMIFUMARATE;XAMOTEROL HEMIFUMARATE SALT
- CBNumber
- CB0249700
- Molecular Formula
- C36H54N6O14
- Formula Weight
- 794.85
- MOL File
- 73210-73-8.mol
Xamoterol hemifumarate Property
- Melting point:
- 168-169° (dec)
- storage temp.
- Store at RT
- solubility
- H2O: 10 mg/mL at 60 °C, soluble
- form
- solid
- color
- white
- CAS DataBase Reference
- 73210-73-8
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 24267
- Product name
- Xamoterol (hemifumarate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24267
- Product name
- Xamoterol (hemifumarate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 24267
- Product name
- Xamoterol (hemifumarate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 24267
- Product name
- Xamoterol (hemifumarate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $420
- Updated
- 2024/03/01
- Product number
- 0950
- Product name
- Xamoterolhemifumarate
- Purity
- ≥97%(HPLC)
- Packaging
- 50
- Price
- $767
- Updated
- 2021/12/16
Xamoterol hemifumarate Chemical Properties,Usage,Production
Description
Xamoterol fumarate is a cardioselective partial beta-agonist, the first of its class to be developed for use in heart failure. The main advantage of xamoterol fumarate as a cardiotonic lies in the fact that its beta-blocking effect exerted during high sympathetic drive will protect the heart from overstimulation. It is claimed to be a viable but safer alternative to digoxin.
Description
Xamoterol is a partial agonist of β1-adrenergic receptors (β1-ARs) with an EC50 value of 80 nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures. It increases spontaneous contraction of isolated rat right atria (EC50 = 4.67 nM). In vivo, xamoterol increases heart rate in beagle dogs (ED50 = 3.2 μg/kg) and in a rat model of spontaneous heart failure (ED50 = 6 μg/kg), an effect that is reversed by the selective β1-AR antagonist betaxolol but not the selective β2-AR antagonist ICI 118551 . Formulations containing xamoterol have been used in the treatment of heart failure.
Originator
ICI (United Kingdom)
Uses
Xamoterol Hemifumarate, is a β1-adrenoceptor-selective partial agonist.
Uses
Stimulant (cardiac).
brand name
Corwin
Biological Activity
β 1 -adrenoceptor-selective partial agonist (pA 2 values are 7.4-7.8 and 5.2-6.2 at β 1 - and β 2 -adrenoceptors respectively).
storage
Store at RT