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Betrixaban

Product Name
Betrixaban
CAS No.
330942-05-7
Chemical Name
Betrixaban
Synonyms
CS-1417;MK-4448;PRT-021;MLN-1021;PRT 054021;Betrixaban;Bertixaban;Betrixaban-d4;Betrixaban, >=98%;Betrixaban USP/EP/BP
CBNumber
CB02500171
Molecular Formula
C23H22ClN5O3
Formula Weight
451.91
MOL File
330942-05-7.mol
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Betrixaban Property

Melting point:
210-213°C
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
11.00±0.70(Predicted)
color 
Off-White
CAS DataBase Reference
330942-05-7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2845
Product name
Betrixaban
Purity
≥98% (HPLC)
Packaging
5MG
Price
$94.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2845
Product name
Betrixaban
Purity
≥98% (HPLC)
Packaging
25MG
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
21563
Product name
Betrixaban
Purity
≥98%
Packaging
25mg
Price
$267
Updated
2024/03/01
Cayman Chemical
Product number
21563
Product name
Betrixaban
Purity
≥98%
Packaging
50mg
Price
$453
Updated
2024/03/01
Cayman Chemical
Product number
21563
Product name
Betrixaban
Purity
≥98%
Packaging
100mg
Price
$692
Updated
2024/03/01
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Betrixaban Chemical Properties,Usage,Production

Uses

Betrixaban is a novel anticoagulant, an oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).

Definition

ChEBI: Betrixaban is a secondary carboxamide obtained by formal condensation of the carboxy group of 4-(N,N-dimethylcarbamimidoyl)benzoic acid with the amino group of 2-amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide. A synthetic anticoagulant compound that targets activated factor Xa in the coagulation cascade. It has a role as an anticoagulant and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a member of guanidines, a member of benzamides, a secondary carboxamide, a monochloropyridine and a monomethoxybenzene.

Biological Activity

betrixaban is a highly potent, selective, and orally efficacious inhibitor of factor xa with ic50 value of 1.5nm [1].betrixaban shows excellent anticoagulant potency in vitro. in the rabbit deep vein thrombosis model, the concentration of betrixaban required to double the rabbit prothrombin time is below 2μm. betrixaban is selective for fxa and has poor activity for thrombin, trypsin, t-pa and apc. the patch clamp herg assay shows that betrixaban has low affinity with herg suggesting it is safer than other candidate compounds. in addition, betrixaban displays a profile of good oral bioavailability and oral exposure, long half-life in animal models. it has bioavailability of 51.6% at dose of 0.5 mg/kg iv and 2.5 mg/kg po. furthermore, the phase ii study has proved betrixaban as an oral fxa inhibitor for prevention of venous thromboembolic events [1].

References

[1] zhang p, huang w, wang l, bao l, jia zj, bauer sm, goldman ea, probst gd, song y, su t, fan j, wu y, li w, woolfrey j, sinha u, wong pw, edwards st, arfsten ae, clizbe la, kanter j, pandey a, park g, hutchaleelaha a, lambing jl, hollenbach sj, scarborough rm, zhu by. discovery of betrixaban (prt054021), n-(5-chloropyridin-2-yl)-2-(4-(n,n-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor xa inhibitor. bioorg med chem lett. 2009 apr 15;19(8):2179-85.

Betrixaban Preparation Products And Raw materials

Raw materials

Preparation Products

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Betrixaban Suppliers

Canada 1 China 152 India 3 United Kingdom 3 United States 17 Global 176
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Molekula Ltd
Tel
--
Fax
--
Email
info@molekula.com
Country
United Kingdom
ProdList
4060
Advantage
50
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View Lastest Price from Betrixaban manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Betrixaban 330942-05-7
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2021-09-13
Anhui Ruihan Technology Co., Ltd
Product
Betrixaban 330942-05-7
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-11
Dideu Industries Group Limited
Product
Betrixaban 330942-05-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-04

330942-05-7, BetrixabanRelated Search:

Osimertinib mesylate Gefitinib PHENRAMINE MALEATE Raltegravir N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Betrixaban Impurity 2 Betrixaban Impurity 1 Bendamustine Argatroban Lercanidipine Trazodone Rivaroxaban

  • Betrixaban
  • N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide
  • Betrixaban, >=98%
  • Betrixaban, PRT-054021
  • 1-C-{4-[aMino(diMethylaMino)Methyl]benzene}-2-N-(5-chloropyridin-2-yl)-4-Methoxybenzene-1,2-dicarboxaMide
  • N-(5-Chloro-2-pyridinyl)-2-[[4-[(diMethylaMino)iMinoMethyl]benzoyl]aMino]-5-MethoxybenzaMide
  • PRT 054021
  • N-(5-chloropyridin-2-yl)-2-(4-(N,N-diMethylcarbaMiMidoyl)benzaMido)-4-MethoxybenzaMide
  • N-(5-CHLOROPYRIDIN-2-YL)-2-(4-(N,N-DIMETHYLCARBAMIMIDOYL)BENZAMIDO)-5-METHOXYBENZAMIDE
  • Betrixaban N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide
  • N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide Betrixaban
  • N-HYDROXY-4-PYRIDAZINECARBOXAMIDE
  • Betrixaban-d4
  • CS-1417
  • BETRIXABAN;MK-4448; PRT-021; PRT-054021; MLN-1021
  • MK-4448
  • MLN-1021
  • PRT-021
  • N-(5-chloropyridin-2-yl)-2-({[4-(N,N-dimethylcarbamimidoyl)phenyl]carbonyl}amino)-5-methoxybenzamide
  • Benzamide, N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-
  • Betrixaban USP/EP/BP
  • Bertixaban
  • N-(5-chloropyridin-2-yl)-2-({[4-(N,N-dimethylcarbamimidoyl)p...
  • 330942-05-7
  • API
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals