Betrixaban

Product Name: Betrixaban
CAS No.: 330942-05-7
Chemical Name: Betrixaban
Synonyms: CS-1417;MK-4448;PRT-021;MLN-1021;PRT 054021;Betrixaban;Bertixaban;Betrixaban-d4;Betrixaban, >=98%;Betrixaban USP/EP/BP
CBNumber: CB02500171
Molecular Formula: C23H22ClN5O3
Formula Weight: 451.91
MOL File: 330942-05-7.mol

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Betrixaban Property

Melting point:: 210-213°C
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 11.00±0.70(Predicted)
color: Off-White
CAS DataBase Reference: 330942-05-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2845
Product name: Betrixaban
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $94.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2845
Product name: Betrixaban
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $381
Updated: 2024/03/01

Cayman Chemical

Product number: 21563
Product name: Betrixaban
Purity: ≥98%
Packaging: 25mg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 21563
Product name: Betrixaban
Purity: ≥98%
Packaging: 50mg
Price: $453
Updated: 2024/03/01

Cayman Chemical

Product number: 21563
Product name: Betrixaban
Purity: ≥98%
Packaging: 100mg
Price: $692
Updated: 2024/03/01

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Betrixaban Chemical Properties,Usage,Production

Uses

Betrixaban is a novel anticoagulant, an oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).

Definition

ChEBI: Betrixaban is a secondary carboxamide obtained by formal condensation of the carboxy group of 4-(N,N-dimethylcarbamimidoyl)benzoic acid with the amino group of 2-amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide. A synthetic anticoagulant compound that targets activated factor Xa in the coagulation cascade. It has a role as an anticoagulant and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a member of guanidines, a member of benzamides, a secondary carboxamide, a monochloropyridine and a monomethoxybenzene.

Biological Activity

betrixaban is a highly potent, selective, and orally efficacious inhibitor of factor xa with ic50 value of 1.5nm [1].betrixaban shows excellent anticoagulant potency in vitro. in the rabbit deep vein thrombosis model, the concentration of betrixaban required to double the rabbit prothrombin time is below 2μm. betrixaban is selective for fxa and has poor activity for thrombin, trypsin, t-pa and apc. the patch clamp herg assay shows that betrixaban has low affinity with herg suggesting it is safer than other candidate compounds. in addition, betrixaban displays a profile of good oral bioavailability and oral exposure, long half-life in animal models. it has bioavailability of 51.6% at dose of 0.5 mg/kg iv and 2.5 mg/kg po. furthermore, the phase ii study has proved betrixaban as an oral fxa inhibitor for prevention of venous thromboembolic events [1].

References

[1] zhang p, huang w, wang l, bao l, jia zj, bauer sm, goldman ea, probst gd, song y, su t, fan j, wu y, li w, woolfrey j, sinha u, wong pw, edwards st, arfsten ae, clizbe la, kanter j, pandey a, park g, hutchaleelaha a, lambing jl, hollenbach sj, scarborough rm, zhu by. discovery of betrixaban (prt054021), n-(5-chloropyridin-2-yl)-2-(4-(n,n-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor xa inhibitor. bioorg med chem lett. 2009 apr 15;19(8):2179-85.

Betrixaban Preparation Products And Raw materials

Raw materials

Preparation Products

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Betrixaban Suppliers

Canada 1 China 152 India 3 United Kingdom 3 United States 17 Global 176

LGM Pharma

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Musechem

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TargetMol Chemicals Inc.

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Alfa Chemistry

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InvivoChem

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Cckinase, Inc.

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Protheragen-ING

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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View Lastest Price from Betrixaban manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Betrixaban 330942-05-7
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2021-09-13

Anhui Ruihan Technology Co., Ltd

Product: Betrixaban 330942-05-7
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-09-11

Dideu Industries Group Limited

Product: Betrixaban 330942-05-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-04

330942-05-7, BetrixabanRelated Search:

Osimertinib mesylate Gefitinib PHENRAMINE MALEATE Raltegravir N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Betrixaban Impurity 2 Betrixaban Impurity 1 Bendamustine Argatroban Lercanidipine Trazodone Rivaroxaban

Betrixaban

N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide

Betrixaban, >=98%

Betrixaban, PRT-054021

1-C-{4-[aMino(diMethylaMino)Methyl]benzene}-2-N-(5-chloropyridin-2-yl)-4-Methoxybenzene-1,2-dicarboxaMide

N-(5-Chloro-2-pyridinyl)-2-[[4-[(diMethylaMino)iMinoMethyl]benzoyl]aMino]-5-MethoxybenzaMide

PRT 054021

N-(5-chloropyridin-2-yl)-2-(4-(N,N-diMethylcarbaMiMidoyl)benzaMido)-4-MethoxybenzaMide

N-(5-CHLOROPYRIDIN-2-YL)-2-(4-(N,N-DIMETHYLCARBAMIMIDOYL)BENZAMIDO)-5-METHOXYBENZAMIDE

Betrixaban N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide

N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide Betrixaban

N-HYDROXY-4-PYRIDAZINECARBOXAMIDE

Betrixaban-d4

CS-1417

BETRIXABAN;MK-4448; PRT-021; PRT-054021; MLN-1021

MK-4448

MLN-1021

PRT-021

N-(5-chloropyridin-2-yl)-2-({[4-(N,N-dimethylcarbamimidoyl)phenyl]carbonyl}amino)-5-methoxybenzamide

Benzamide, N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-

Betrixaban USP/EP/BP

Bertixaban

N-(5-chloropyridin-2-yl)-2-({[4-(N,N-dimethylcarbamimidoyl)p...

330942-05-7

API

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals