ChemicalBook > CAS DataBase List > 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

Product Name
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
CAS No.
137977-97-0
Chemical Name
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Synonyms
1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 39;Tolvaptan Impurity 10;Histaprodifen Impurity 1;Tolvaptan Intermediate 3;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1...;1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one;1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
CBNumber
CB02500621
Molecular Formula
C18H17ClN2O2
Formula Weight
328.79
MOL File
137977-97-0.mol
More
Less

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Property

Melting point:
186-189°C
Boiling point:
565.4±50.0 °C(Predicted)
Density 
1.320
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
2.28±0.10(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
InChI
InChI=1S/C18H17ClN2O2/c1-11-9-13(20)5-6-14(11)18(23)21-8-2-3-17(22)15-10-12(19)4-7-16(15)21/h4-7,9-10H,2-3,8,20H2,1H3
InChIKey
FLJCJPKXJWRZJB-UHFFFAOYSA-N
SMILES
N1(C(=O)C2=CC=C(N)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FA151721
Product name
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Packaging
500mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
Z3611
Product name
7-Chloro-1-(4-amino-2-methylbenzoyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging
250mg
Price
$131
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151721
Product name
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Packaging
1g
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151721
Product name
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Packaging
2g
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151721
Product name
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Packaging
5G
Price
$400
Updated
2021/12/16
More
Less

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Chemical Properties,Usage,Production

Uses

1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V2 receptor antagonist.

Uses

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V 2 receptor antagonist.

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Suppliers

Canada 1 China 119 India 8 United Kingdom 1 United States 4 Global 133
Enki Biopharmaceuticals(Shanghai) Limited
Tel
021-57680965 13916707528
Fax
(21) 5768 0922
Email
yusu@enkibiopharma.com
Country
China
ProdList
52
Advantage
55
Jiangxi Jinfeng Pharmaceutical Co., Ltd
Tel
793-5181188 18170363299
Email
yangyuening@jxjfpharma.com
Country
China
ProdList
66
Advantage
58
Suzhou Junye Biopharmaceutical Technology Co., Ltd
Tel
0512-53662086-8001 18913766772
Email
wangli@jyk-biotech.com
Country
China
ProdList
473
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Hangzhou Luckysage Sciene and Technology Co.,Ltd
Tel
0571-0571-88199336 13355710209
Fax
0571-88190523
Email
sales@luckysagechem.com
Country
China
ProdList
56
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4388
Advantage
65
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
4973
Advantage
50
More
Less

View Lastest Price from 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one manufacturers

Enki Biopharmaceuticals (Shanghai) Limited
Product
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137977-97-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
5000
Release date
2024-01-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137977-97-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KGS
Release date
2021-11-08
Changzhou Rokechem Technology Co., Ltd.
Product
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137977-97-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99%
Supply Ability
1-10000kgs
Release date
2023-07-06

137977-97-0, 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-oneRelated Search:

Tolvaptan Impurity 11 Tolvaptan Impurity 26 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one 2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 4 (DM-4105) Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester Tolvaptan Impurity 21 Tolvaptan Impurity 18 Tolvaptan Impurity 13 Tolvaptan Impurity 17 Tolvaptan impurity 2 Tolvaptan Impurity 20

  • 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
  • 5H-1-Benzazepin-5-one, 1-(4-aMino-2-Methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-
  • 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one
  • 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
  • Tolvaptan Impurity 10
  • 1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
  • 1-(4-Amino-2-Methylbenzoyl)-7-Chloro-1,2,3,4-Tetrahydro-5H-1-benzazepine-5-One
  • 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
  • 1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one
  • Tolvaptan Intermediate 3
  • 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1...
  • 1-(4- amino -2- methylbenzoyl) -7- chloro -1,2,3,4- tetrahydro -5H-1- benzoazepine -5- one *
  • Tovaptan impurity 39
  • Histaprodifen Impurity 1
  • 7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
  • 137977-97-0
  • Pharmaceutical Intermediates
  • 137977-97-0