ChemicalBook > CAS DataBase List > 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

Product Name
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
CAS No.
160129-45-3
Chemical Name
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
Synonyms
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-Chlorobenzo[b]azepan-5-one;7-chloro-2,3,4,5-tetrahydro-;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
CBNumber
CB7477186
Molecular Formula
C10H10ClNO
Formula Weight
195.65
MOL File
160129-45-3.mol
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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Property

Melting point:
103.0 to 107.0 °C
Boiling point:
356.5±41.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
2.36±0.20(Predicted)
color 
Off-White to Pale Yellow
InChI
InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey
AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES
N1C2=CC=C(Cl)C=C2C(=O)CCC1
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2896
Product name
7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$81
Updated
2024/03/01
TCI Chemical
Product number
C2896
Product name
7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$321
Updated
2024/03/01
TRC
Product number
C366265
Product name
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging
10g
Price
$415
Updated
2021/12/16
Usbiological
Product number
162272
Product name
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging
1g
Price
$418
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC51283
Product name
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging
100g
Price
$500
Updated
2021/12/16
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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Suppliers

Jiangxi Jinfeng Pharmaceutical Co., Ltd
Tel
793-5181188 18170363299
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yangyuening@jxjfpharma.com
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China
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Sinfachem Limited.
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025-84683399 13952017251
Email
sinfachem@foxmail.com
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China
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Enki Biopharmaceuticals(Shanghai) Limited
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021-57680965 13916707528
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(21) 5768 0922
Email
yusu@enkibiopharma.com
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China
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Zhenjiang Carbochem Pharmatech Co.,LTD
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0511-82018158 18136818960
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sales4@carbo-chem.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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sales@BioChemBest.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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sales@capotchem.com
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China
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JinYan Chemicals(ShangHai) Co.,Ltd.
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13817811078
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86-021-50426522,50426273
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sales@jingyan-chemical.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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View Lastest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Enki Biopharmaceuticals (Shanghai) Limited
Product
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 160129-45-3
Price
US $0.00/kg
Min. Order
25kg
Purity
99.0%
Supply Ability
10000
Release date
2023-11-24
HEBEI BRANT PHARMACEUTICAL CO.,LTD
Product
7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one 160129-45-3
Price
US $0.00-0.00/kg
Min. Order
100kg
Purity
≥99.0%
Supply Ability
20 tons
Release date
2024-07-31
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Tolvaptan Impurity 9 160129-45-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-12

160129-45-3, 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-oneRelated Search:


  • 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
  • 7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone
  • 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
  • 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one
  • Tolvaptan Impurity 29
  • 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-
  • 7-Chlorobenzo[b]azepan-5-one
  • 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one
  • 7-Chloro-1,2,3,4-tetrahydro-5<i>H</i>-1-benzazepin-5-one
  • 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
  • 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE
  • 7-chloro-2,3,4,5-tetrahydro-
  • 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one
  • 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one &gt
  • 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones
  • 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
  • Tovaptan impurity 29
  • Tovaptan impurity 24
  • 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One
  • Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
  • 160129-45-3
  • Building Blocks/Intermediates
  • Tolvaptan intermediate