ChemicalBook > CAS DataBase List > 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

Product Name
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
CAS No.
160129-45-3
Chemical Name
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
Synonyms
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-Chlorobenzo[b]azepan-5-one;7-chloro-2,3,4,5-tetrahydro-;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
CBNumber
CB7477186
Molecular Formula
C10H10ClNO
Formula Weight
195.65
MOL File
160129-45-3.mol
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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Property

Melting point:
103.0 to 107.0 °C
Boiling point:
356.5±41.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
2.36±0.20(Predicted)
color 
Off-White to Pale Yellow
InChI
InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey
AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES
N1C2=CC=C(Cl)C=C2C(=O)CCC1
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2896
Product name
7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$81
Updated
2024/03/01
TCI Chemical
Product number
C2896
Product name
7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$321
Updated
2024/03/01
TRC
Product number
C366265
Product name
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging
10g
Price
$415
Updated
2021/12/16
Usbiological
Product number
162272
Product name
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging
1g
Price
$418
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC51283
Product name
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging
100g
Price
$500
Updated
2021/12/16
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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Suppliers

Americas 1 Canada 1 China 242 Europe 1 Germany 1 India 24 Japan 2 United Kingdom 5 United States 16 Global 293
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
HighChem Co.,Ltd
Tel
--
Fax
--
Country
Japan
ProdList
115
Advantage
58
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View Lastest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Enki Biopharmaceuticals (Shanghai) Limited
Product
7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one 160129-45-3
Price
US $0.00/kg
Min. Order
25kg
Purity
99.0%
Supply Ability
10000
Release date
2023-11-24
HEBEI BRANT PHARMACEUTICAL CO.,LTD
Product
7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one 160129-45-3
Price
US $0.00-0.00/kg
Min. Order
100kg
Purity
≥99.0%
Supply Ability
20 tons
Release date
2024-07-31
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Tolvaptan Impurity 9 160129-45-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-12

160129-45-3, 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-oneRelated Search:

2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2 Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 6-CHLORO-1H-BENZIMIDAZOLE 6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-CHLORO-9-METHOXY-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

  • 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
  • 7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone
  • 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
  • 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one
  • Tolvaptan Impurity 29
  • 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-
  • 7-Chlorobenzo[b]azepan-5-one
  • 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one
  • 7-Chloro-1,2,3,4-tetrahydro-5<i>H</i>-1-benzazepin-5-one
  • 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
  • 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE
  • 7-chloro-2,3,4,5-tetrahydro-
  • 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one
  • 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one &gt
  • 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones
  • 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
  • Tovaptan impurity 29
  • Tovaptan impurity 24
  • 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One
  • Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
  • 160129-45-3
  • Building Blocks/Intermediates
  • Tolvaptan intermediate