7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

ChemicalBook > CAS DataBase List > 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

Product Name: 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
CAS No.: 160129-45-3
Chemical Name: 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
Synonyms: 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-Chlorobenzo[b]azepan-5-one;7-chloro-2,3,4,5-tetrahydro-;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
CBNumber: CB7477186
Molecular Formula: C10H10ClNO
Formula Weight: 195.65
MOL File: 160129-45-3.mol

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Property

Melting point:: 103.0 to 107.0 °C
Boiling point:: 356.5±41.0 °C(Predicted)
Density: 1.234±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 2.36±0.20(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey: AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES: N1C2=CC=C(Cl)C=C2C(=O)CCC1

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2896
Product name: 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $81
Updated: 2024/03/01

TCI Chemical

Product number: C2896
Product name: 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $321
Updated: 2024/03/01

TRC

Product number: C366265
Product name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging: 10g
Price: $415
Updated: 2021/12/16

Usbiological

Product number: 162272
Product name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging: 1g
Price: $418
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC51283
Product name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging: 100g
Price: $500
Updated: 2021/12/16

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Enki Biopharmaceuticals (Shanghai) Limited

Product: 7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one 160129-45-3
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 10000
Release date: 2023-11-24

Henan Aochuang Chemical Co.,Ltd.

Product: 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 160129-45-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Cangzhou Wanyou New Material Technology Co.,Ltd

Product: 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 160129-45-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 2 tons
Release date: 2019-08-04

160129-45-3, 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-oneRelated Search:

2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2 Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 6-CHLORO-1H-BENZIMIDAZOLE 6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-CHLORO-9-METHOXY-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone

7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one

7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one

Tolvaptan Impurity 29

5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-

7-Chlorobenzo[b]azepan-5-one

7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

7-Chloro-1,2,3,4-tetrahydro-5<i>H</i>-1-benzazepin-5-one

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE

7-chloro-2,3,4,5-tetrahydro-

7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one

7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one &gt

7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones

7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Tovaptan impurity 29

Tovaptan impurity 24

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One

Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one

160129-45-3

Building Blocks/Intermediates

Tolvaptan intermediate