7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

ChemicalBook > CAS DataBase List > 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

Product Name: 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
CAS No.: 160129-45-3
Chemical Name: 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
Synonyms: 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-Chlorobenzo[b]azepan-5-one;7-chloro-2,3,4,5-tetrahydro-;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
CBNumber: CB7477186
Molecular Formula: C10H10ClNO
Formula Weight: 195.65
MOL File: 160129-45-3.mol

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Property

Melting point:: 103.0 to 107.0 °C
Boiling point:: 356.5±41.0 °C(Predicted)
Density: 1.234±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 2.36±0.20(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey: AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES: N1C2=CC=C(Cl)C=C2C(=O)CCC1

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2896
Product name: 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $81
Updated: 2024/03/01

TCI Chemical

Product number: C2896
Product name: 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $321
Updated: 2024/03/01

TRC

Product number: C366265
Product name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging: 10g
Price: $415
Updated: 2021/12/16

Usbiological

Product number: 162272
Product name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging: 1g
Price: $418
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC51283
Product name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Packaging: 100g
Price: $500
Updated: 2021/12/16

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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Enki Biopharmaceuticals (Shanghai) Limited

Product: 7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one 160129-45-3
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99.0%
Supply Ability: 10000
Release date: 2023-11-24

HEBEI BRANT PHARMACEUTICAL CO.,LTD

Product: 7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one 160129-45-3
Price: US $0.00-0.00/kg
Min. Order: 100kg
Purity: ≥99.0%
Supply Ability: 20 tons
Release date: 2024-07-31

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Tolvaptan Impurity 9 160129-45-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-08-12

160129-45-3, 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-oneRelated Search:

2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2 Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 6-CHLORO-1H-BENZIMIDAZOLE 6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-CHLORO-9-METHOXY-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone

7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one

7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one

Tolvaptan Impurity 29

5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-

7-Chlorobenzo[b]azepan-5-one

7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

7-Chloro-1,2,3,4-tetrahydro-5<i>H</i>-1-benzazepin-5-one

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE

7-chloro-2,3,4,5-tetrahydro-

7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one

7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one &gt

7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones

7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Tovaptan impurity 29

Tovaptan impurity 24

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One

Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one

160129-45-3

Building Blocks/Intermediates

Tolvaptan intermediate