(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol

Product Name: (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
CAS No.: 875573-67-4
Chemical Name: (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Synonyms: Fulvestrant int3;Fulvestrant Impurity 43;Fulvestrant intermediate N-2;Fulvestrant interMediate N-2(1);Fulvestrant Intermediates--5-1(N-3-1);Fulvestrant intermediate N-3 hydrolysate;7α-(9-Bromononyl)estra-1,3,5(10)-triene-3,17β-diol;(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol;(7α,17β)-7-(9-bromononyl)estra-1,3,5(10)-triene-3,17-diol;"(7α,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol"
CBNumber: CB02500681
Molecular Formula: C27H41BrO2
Formula Weight: 477.53
MOL File: 875573-67-4.mol

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(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Property

Boiling point:: 586.1±50.0 °C(Predicted)
Density: 1.196
storage temp.: Sealed in dry,Room Temperature
pka: 10.27±0.70(Predicted)
InChIKey: ILWDBZWOZQESSY-RIVKPNGLNA-N
SMILES: C([C@@H]1CC2=CC(O)=CC=C2[C@@]2([H])CC[C@@]3([C@@H](O)CC[C@@]3([H])[C@]12[H])C)CCCCCCCCBr |&1:1,10,14,15,19,21,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B687533
Product name: (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152400
Product name: (7a,17beta)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging: 250ug
Price: $67.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152400
Product name: (7a,17beta)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging: 500ug
Price: $115
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152400
Product name: (7a,17beta)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging: 2mg
Price: $352
Updated: 2021/12/16

Matrix Scientific

Product number: 095273
Product name: (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Purity: 95+%
Packaging: 1g
Price: $385
Updated: 2021/12/16

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(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Chemical Properties,Usage,Production

Uses

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol is used in the synthetic preparation of 7α-alkylated 19-norsteroids.

Definition

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol is a Fulvestrant intermediate.

Synthesis

875573-66-3

875573-67-4

Synthesis of (7R,8R,9S,13S,14S,17S)-7-(9-bromononyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a ]phenanthrene-3,17-diol was performed in the following general steps: the compound of Formula II (5.0 g) prepared in Example 1 was added to a reaction flask with methanol (50 mL) and heated until dissolved. Subsequently, aqueous hydrobromic acid (5 mL of 40 mL) was slowly added and the reaction was carried out at 60 °C for 2 hours. After completion of the reaction, it was cooled to room temperature and the solid product was collected by filtration. The resulting solid was dried in a vacuum oven at 40 °C for 8 h to afford the compound of formula III (4.3 g), which was tested to be 97.7% pure.

References

[1] Patent: US2006/30552, 2006, A1. Location in patent: Page/Page column 25
[2] Patent: CN107325143, 2017, A. Location in patent: Paragraph 0010; 0011; 0012

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Preparation Products And Raw materials

Raw materials

Preparation Products

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(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Suppliers

China 136 India 2 United Kingdom 1 United States 4 Global 143

Protheragen-ING

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View Lastest Price from (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol 875573-67-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Hebei Yanxi Chemical Co., Ltd.

Product: (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol 875573-67-4
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-19

Career Henan Chemical Co

Product: (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol 875573-67-4
Price: US $150.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-07-27

875573-67-4, (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diolRelated Search:

Estra-1,3,5(10)-triene-3,17-diol, 7-(9-broMononyl)-, (7a,17b)- (9CI)

Fulvestrant Intermediates--5-1(N-3-1)

Estra-1,3,5(10)-triene-3,17-diol, 7-(9-bromononyl)-, (7α,17β)-

(7A,17BETA)-7-(9-BROMONONYL)ESTRA-1,3,5(10)-TRIENE-3,17-DIOL

(7α,17β)-7-(9-bromononyl)estra-1,3,5(10)-triene-3,17-diol

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol

Fulvestrant interMediate N-2(1)

(7R,8R,9S,13S,14S,17S)-7-(9-bromononyl)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Fulvestrant int3

(7a,17b)-7-(9-Bromononyl)Estra-1,3,5(10)-Triene-3,17-Diol(For export only)

Fulvestrant Impurity 43

"(7α,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol"

Fulvestrant intermediate N-2

(7R,8R,9S,13S,14S,17S)-7-(9-Bromononyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Fulvestrant intermediate N-3 hydrolysate

7α-(9-Bromononyl)estra-1,3,5(10)-triene-3,17β-diol

875573-67-4

C27H41BrO2