TW-37
- Product Name
- TW-37
- CAS No.
- 877877-35-5
- Chemical Name
- TW-37
- Synonyms
- TW-37;CS-299;TW37;TW 37;TW-37 USP/EP/BP;TW-37/Bcl-2Inhibitor;inhibit,Bcl-2 Family,TW37,TW-37,Inhibitor;5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide;N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide;TW-37/N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide;N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
- CBNumber
- CB02500999
- Molecular Formula
- C33H35NO6S
- Formula Weight
- 573.7
- MOL File
- 877877-35-5.mol
TW-37 Property
- Boiling point:
- 723.7±60.0 °C(Predicted)
- Density
- 1.280
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic
- form
- A crystalline solid
- pka
- 7.86±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20999
- Product name
- TW-37
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 20999
- Product name
- TW-37
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $185
- Updated
- 2024/03/01
- Product number
- 20999
- Product name
- TW-37
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $380
- Updated
- 2024/03/01
- Product number
- 20999
- Product name
- TW-37
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $648
- Updated
- 2024/03/01
- Product number
- 4038
- Product name
- TW37
- Purity
- ≥97%(HPLC)
- Packaging
- 50
- Price
- $835
- Updated
- 2021/12/16
TW-37 Chemical Properties,Usage,Production
Description
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously. It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.
Uses
TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.
Uses
TW-37 is a Bcl-2 inhibitor that suppresses growth and enhance cisplatin-induced apoptosis in ovarian cancer cells. Also functions as an MCL-1 inhibitor that kills many more malignant cells.
Definition
ChEBI: N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide is a member of benzamides.
TW-37 Preparation Products And Raw materials
Raw materials
Preparation Products
TW-37 Suppliers
View Lastest Price from TW-37 manufacturers
- Product
- TW-37 877877-35-5
- Price
- US $0.01/KG
- Min. Order
- 500g
- Purity
- 98%; 99%
- Supply Ability
- 500g；1kg； 10kg; 25kg
- Release date
- 2020-01-08