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Obatoclax mesilate

Product Name
Obatoclax mesilate
CAS No.
803712-79-0
Chemical Name
Obatoclax mesilate
Synonyms
Obato;CS-393;Gx 15-070;Gx015-070;Gx 15-070ms;Unii-39200fj43j;GX15070 Mesylate;GX15 070 Mesylate;GX15-070 Mesylate;OBATOCLAX MESYLATE
CBNumber
CB21011539
Molecular Formula
C20H19N3O.CH4O3S
Formula Weight
413.49
MOL File
803712-79-0.mol
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Obatoclax mesilate Property

storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 5 mg/ml).
form 
solid
color 
Purple
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
5mg
Price
$180
Updated
2024/03/01
Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
10mg
Price
$330
Updated
2024/03/01
Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
50mg
Price
$893
Updated
2024/03/01
Tocris
Product number
6539
Product name
Obatoclaxmesylate
Purity
≥98%(HPLC)
Packaging
50
Price
$730
Updated
2021/12/16
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Obatoclax mesilate Chemical Properties,Usage,Production

Description

Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.

Chemical Properties

Red powder

Uses

Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.

Uses

Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.

storage

Store at -20°C

References

1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149 2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413 3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789 4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409

Obatoclax mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

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Obatoclax mesilate Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
579
Advantage
61
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
Tianjin YongSheng Biotechnology Co., Ltd.
Tel
022-60987737 13512258274
Fax
86-022-23500597
Email
sales@immortalbio.com
Country
China
ProdList
155
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
China Kouting Group Limited
Tel
+86 (21) 5811-6473 5811-6475
Fax
+86 (21) 6129-4103
Email
sales@koutingchina.com
Country
China
ProdList
496
Advantage
60
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View Lastest Price from Obatoclax mesilate manufacturers

Career Henan Chemical Co
Product
Obatoclax mesilate 803712-79-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

803712-79-0, Obatoclax mesilateRelated Search:


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