ChemicalBook > CAS DataBase List > Obatoclax mesilate

Obatoclax mesilate

Product Name: Obatoclax mesilate
CAS No.: 803712-79-0
Chemical Name: Obatoclax mesilate
Synonyms: Obato;CS-393;Gx 15-070;Gx015-070;Gx 15-070ms;Unii-39200fj43j;GX15070 Mesylate;GX15 070 Mesylate;GX15-070 Mesylate;OBATOCLAX MESYLATE
CBNumber: CB21011539
Molecular Formula: C20H19N3O.CH4O3S
Formula Weight: 413.49
MOL File: 803712-79-0.mol

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Obatoclax mesilate Property

storage temp.: -20°C
solubility: Soluble in DMSO (up to 5 mg/ml).
form: solid
color: Purple
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 5mg
Price: $180
Updated: 2024/03/01

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 10mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 11499
Product name: Obatoclax (mesylate)
Purity: ≥98%
Packaging: 50mg
Price: $893
Updated: 2024/03/01

Tocris

Product number: 6539
Product name: Obatoclaxmesylate
Purity: ≥98%(HPLC)
Packaging: 50
Price: $730
Updated: 2021/12/16

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Obatoclax mesilate Chemical Properties,Usage,Production

Description

Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.

Chemical Properties

Red powder

Uses

Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.

Uses

Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.

in vivo

Obatoclax Mesylate (GX15-070 Mesylate; 1.15-5 mg/kg; intravenously injected; five consecutive days) exhibits potent antitumor activity in xenograft mouse models in a dose-dependent manner^[4].

Animal Model:	6-8 weeks old female BALB/C nude mice bearing subcutaneous tumors^[4]
Dosage:	1.15, 2.5, 5 mg/kg
Administration:	Intravenously injected (through lateral tail vein); five consecutive days (i.e. 5 injections)
Result:	Exhibited potent antitumor activity in xenograft mouse models in a dose-dependent manner.

IC 50

Bcl-2: 220 nM (Ki); Mcl-1: 1-7 μM (Ki); Bcl-xL: 1-7 μM (Ki); Bcl-W: 1-7 μM (Ki); Bcl-B: 1-7 μM (Ki)

storage

Store at -20°C

References

[1] T NI CHONGHAILE A L. Mimicking the BH3 domain to kill cancer cells.[J]. Oncogene, 2008, 27 Suppl 1: S149-57. DOI:10.1038/onc.2009.52
[2] MARINA KONOPLEVA. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).[J]. Cancer research, 2008: 3413-3420. DOI:10.1158/0008-5472.can-07-1919
[3] GUAN WANG. Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells.[J]. Oncology reports, 2014, 32 6: 2789-2794. DOI:10.3892/or.2014.3525
[4] CHENGZHI XIE . Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage[J]. Molecular Oncology, 2015, 9 2: Pages 409-421. DOI:10.1016/j.molonc.2014.09.008

Obatoclax mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Obatoclax mesilate manufacturers

Career Henan Chemical Co

Product: Obatoclax mesilate 803712-79-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

803712-79-0, Obatoclax mesilateRelated Search:

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OBATOCLAX MESYLATE

2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate

Obatoclax mesilate

1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-, monomethanesulfonate

Gx 15-070

Gx 15-070ms

Gx015-070

Unii-39200fj43j

Obatoclax (GX15-070)

Obatoclax, Methanesulfonate Salt

Obatoclax Mesylate (GX15-070)

CS-393

GX-15070, Obatoclax Mesylate

2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfo

(Z)-2-(5-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1H-indole mesylate

Obatoclax mesylate, >=98%

2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonat

Obatoclax mesylate(GX 015070)

Obatoclax mesilate USP/EP/BP

Obato

GX15 070 Mesylate

GX15070 Mesylate

GX15-070 Mesylate

Obatoclax Mesylate, 10 mM in DMSO

803712-79-0

C20H19N3OCH4O3S

Inhibitors

Inhibitor

INDOLE