Obatoclax mesilate
- Product Name
- Obatoclax mesilate
- CAS No.
- 803712-79-0
- Chemical Name
- Obatoclax mesilate
- Synonyms
- Obato;CS-393;Gx 15-070;Gx015-070;Gx 15-070ms;Unii-39200fj43j;GX15070 Mesylate;GX15 070 Mesylate;GX15-070 Mesylate;OBATOCLAX MESYLATE
- CBNumber
- CB21011539
- Molecular Formula
- C20H19N3O.CH4O3S
- Formula Weight
- 413.49
- MOL File
- 803712-79-0.mol
Obatoclax mesilate Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 5 mg/ml).
- form
- solid
- color
- Purple
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 11499
- Product name
- Obatoclax (mesylate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 11499
- Product name
- Obatoclax (mesylate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $180
- Updated
- 2024/03/01
- Product number
- 11499
- Product name
- Obatoclax (mesylate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $330
- Updated
- 2024/03/01
- Product number
- 11499
- Product name
- Obatoclax (mesylate)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $893
- Updated
- 2024/03/01
- Product number
- 6539
- Product name
- Obatoclaxmesylate
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
Obatoclax mesilate Chemical Properties,Usage,Production
Description
Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.
Chemical Properties
Red powder
Uses
Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.
Uses
Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.
storage
Store at -20°C
References
1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149 2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413 3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789 4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409
Obatoclax mesilate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Obatoclax mesilate manufacturers
- Product
- Obatoclax mesilate 803712-79-0
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23