ChemicalBook > CAS DataBase List > Obatoclax mesilate

Obatoclax mesilate

Product Name
Obatoclax mesilate
CAS No.
803712-79-0
Chemical Name
Obatoclax mesilate
Synonyms
Obato;CS-393;Gx 15-070;Gx015-070;Gx 15-070ms;Unii-39200fj43j;GX15070 Mesylate;GX15 070 Mesylate;GX15-070 Mesylate;OBATOCLAX MESYLATE
CBNumber
CB21011539
Molecular Formula
C20H19N3O.CH4O3S
Formula Weight
413.49
MOL File
803712-79-0.mol
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Obatoclax mesilate Property

storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 5 mg/ml).
form 
solid
color 
Purple
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
5mg
Price
$180
Updated
2024/03/01
Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
10mg
Price
$330
Updated
2024/03/01
Cayman Chemical
Product number
11499
Product name
Obatoclax (mesylate)
Purity
≥98%
Packaging
50mg
Price
$893
Updated
2024/03/01
Tocris
Product number
6539
Product name
Obatoclaxmesylate
Purity
≥98%(HPLC)
Packaging
10
Price
$173
Updated
2021/12/16
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Obatoclax mesilate Chemical Properties,Usage,Production

Description

Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.

Chemical Properties

Red powder

Uses

Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.

Uses

Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.

storage

Store at -20°C

References

1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149 2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413 3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789 4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409

Obatoclax mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Obatoclax mesilate manufacturers

Career Henan Chemical Co
Product
Obatoclax mesilate 803712-79-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

803712-79-0, Obatoclax mesilateRelated Search:


  • OBATOCLAX MESYLATE
  • 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
  • Obatoclax mesilate
  • 1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-, monomethanesulfonate
  • Gx 15-070
  • Gx 15-070ms
  • Gx015-070
  • Unii-39200fj43j
  • Obatoclax (GX15-070)
  • Obatoclax, Methanesulfonate Salt
  • Obatoclax Mesylate (GX15-070)
  • CS-393
  • GX-15070, Obatoclax Mesylate
  • 2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfo
  • (Z)-2-(5-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1H-indole mesylate
  • Obatoclax mesylate, >=98%
  • 2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonat
  • Obatoclax mesylate(GX 015070)
  • Obatoclax mesilate USP/EP/BP
  • Obato
  • GX15 070 Mesylate
  • GX15070 Mesylate
  • GX15-070 Mesylate
  • 803712-79-0
  • C20H19N3OCH4O3S
  • Inhibitors
  • Inhibitor
  • INDOLE